Results 221 to 230 of about 479,049 (311)

Using flow cytometry for paediatric leukaemia diagnosis in Kenya: a protocol for mixed methods study. [PDF]

BMJ Open
Severance T, Lotodo T, Serem E, Njuguna F, Melly B, Orido M, Tonui R, Olbara G, Koima R, Kigen N, Kussick S, Ratliff V, Holl E, Monahan PO, Boova T, Vik T.   +15 more
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

E-health supported referral for patients with breast abnormalities at primary healthcare facilities in Ethiopia: protocol for a cluster-randomised controlled trial. [PDF]

Trials
Getachew E, Gizaw M, Anberber E, Shita A, Destaw A, Rossner SS, Tesfaw A, Addissie A, Kantelhardt EJ, Kroeber ES, Getachew S.   +10 more
europepmc   +1 more source

Highlighting Recent Progress in Fiber Energy Harvesters: From Working Principles to Future Perspectives

Advanced Science, EarlyView.
Fiber energy harvesters offer unprecedented flexibility and a unique capacity for integration into commercial textiles, overcoming the limitations of bulky and rigid conventional devices. This review summarizes recent advances in fiber‐based energy harvesting and provides strategic outlooks to accelerate technological progress in the field. ABSTRACT As
Hanhwi Jang, Junseong Ahn, Yongrok Jeong, Sohee Jeon, Soon Hyoung Hwang, Min‐Wook Oh, Jun‐Ho Jeong, Inkyu Park, Yeon Sik Jung   +8 more
wiley   +1 more source

"Correcting Misinformation is Challenging": Exploring Barriers and Facilitators of Health Care Providers' Responsiveness to Cervical Cancer Screening Literacy Needs of Rural Women Living With HIV in Eastern Uganda. [PDF]

Cancer Control
Namutundu J, Nakku-Joloba E, Kiguli J, Makumbi F, Semitala FC, Wanyenze RK, Laker-Oketta M, Nakanjako D, Nakalembe M.   +8 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Readiness to transition to HPV self-collection from VIA screening: a mixed methods health systems assessment from Tamil Nadu, India. [PDF]

BMC Health Serv Res
Oommen AM, Ashfaq M, Viswanathan V, Singarayar P, Muniswamy V, Palaniraja S, D PR, Ravikumar HS, Jeyapaul S, Kane S, Selvinayagam TS, Basu P, Brotherton JML.   +12 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Health system barriers and facilitators influencing the uptake of cervical cancer screening among women in sub-Saharan Africa: systematic review and meta-synthesis. [PDF]

BMC Health Serv Res
Daniels-Donkor SS, Marryat L.
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source