Results 81 to 90 of about 5,397,815 (312)
HPV-associated cancers: cancer trends report [PDF]
Human papilloma virus (HPV) is a group of viruses known to infect the genital area, as well as the mouth and the throat. There are 13 HPV subtypes which are considered high-risk, as these are more likely to cause cell changes that over time can develop ...
National Cancer Registry Ireland (NCRI)
core
Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer.
, 2022 The retinoblastoma tumor suppressor (RB) is a critical regulator of E2F-dependent transcription, controlling a multitude of protumorigenic networks including but not limited to cell-cycle control.
Mandigo, AC +13 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
BioengineeringMicroarray gene expression analysis is a powerful technique used in cancer classification and research to identify and understand gene expression patterns that can differentiate between different cancer types, subtypes, and stages.
Karthika M S +2 more
doaj +1 more source
, 2012 Mesothelioma is a rare cancer of the thin lining that mainly covers the lungs and abdominal cavity. An average of 24 cases of mesothelioma was diagnosed per year in Ireland between 1994 and 2010 (Table 1), representing less than 0.2% of all invasive ...
National Cancer Registry Ireland (NCRI)
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Enhancing Cancer Classification from RNA Sequencing Data Using Deep Learning and Explainable AI
Machine Learning and Knowledge ExtractionCancer is one of the most deadly diseases, costing millions of lives and billions of USD every year. There are different ways to identify the biomarkers that can be used to detect cancer types and subtypes.
Haseeb Younis, Rosane Minghim
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Machine Learning and Knowledge ExtractionQuantum machine learning (QML) has emerged as a promising approach for analyzing the complex, high-dimensional data encountered in oncology, yet research in this area remains fragmented.
Khairil Imran Ghauth +1 more
doaj +1 more source
Cancer Trends: Cancer of the pancreas
, 2012 Cancer of the pancreas accounts for approximately 2.5% of all invasive cancers and is the 9th most commonly diagnosed cancer in Ireland.1 Almost 400 cases of pancreatic cancer were diagnosed annually between 1994 and 2010 (Table 1).
National Cancer Registry Ireland (NCRI)
core