Results 1 to 10 of about 69 (67)
Clinical Chemistry, 2010 10.1373/clinchem.2010.152140 ; Clinical Chemistry ; 56 ; 11 ; 1660-1664 ...
Diamandis, E.P. +4 more
openaire +3 more sources
Archives of Medical Research, 2022 In the past decade, genomics has fundamentally changed our view of cancer biology, allowing comprehensive analyses of mutations, copy number alterations, structural variants, gene expression and DNA methylation profiles in large-scale studies across different cancer types.
Marco A. Fonseca-Montaño +3 more
openaire +2 more sources
Nature, 2009 All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of ...
Peter J. Campbell +4 more
openaire +3 more sources
Nature, 2001 Identification of the genes that cause oncogenesis is a central aim of cancer research. We searched the proteins predicted from the draft human genome sequence for paralogues of known tumour suppressor genes, but no novel genes were identified. We then assessed whether it was possible to search directly for oncogenic sequence changes in cancer cells by
Ewan Birney +5 more
openaire +3 more sources
Functional genomics of complex cancer genomes
Nature Communications, 2022 Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities ...
Francesca Menghi, Edison T. Liu
openaire +4 more sources
APMIS, 2007 Almost all cells in the human body contain a complete copy of the genome with an estimated number of 25,000 genes. The sequences of these genes make up about three percent of the genome and comprise the inherited set of genetic information. The genome also contains information that determines when and where in the organism a given gene is active.
Norrild, Bodil +2 more
openaire +3 more sources
Evolution of the cancer genome [PDF]
Trends in Genetics, 2012 Human tumors result from an evolutionary process operating on somatic cells within tissues, whereby natural selection operates on the phenotypic variability generated by the accumulation of genetic, genomic and epigenetic alterations. This somatic evolution leads to adaptations such as increased proliferative, angiogenic, and invasive phenotypes.
Franziska Michor +3 more
openaire +7 more sources
Proceedings of the American Thoracic Society, 2009 This review focuses on recent research using genomics to examine lung carcinogenesis, histologic differentiation, and progression.
Rebecca L. Toonkel +2 more
openaire +3 more sources
Cancer Cell, 2002 The draft human genome sequence and the dissemination of high throughput technology provides opportunities for systematic analysis of cancer cells. Genome-wide mutation screens, high resolution analysis of chromosomal abberations and expression profiling all give comprehensive views of genetic alterations in cancer cells.
openaire +2 more sources
Progress of cancer genomics [PDF]
Thoracic Cancer, 2015 For hundreds of years, cancer has remained a mystery, threatening the life expectancy and quality of all human beings. Early studies of cancer concluded that all cancers are influenced by genetic variation (germline and/or somatic), environmental agents, and/or health behaviors.
openaire +3 more sources