Results 91 to 100 of about 260,681 (237)

Cancer Networks: A general theoretical and computational framework for understanding cancer [PDF]

arXiv, 2011
We present a general computational theory of cancer and its developmental dynamics. The theory is based on a theory of the architecture and function of developmental control networks which guide the formation of multicellular organisms. Cancer networks are special cases of developmental control networks.
arxiv  

Studying breast cancer on a genomic scale using DNA microarrays [PDF]

, 2000
David Botstein, PO Brown
openalex   +1 more source

Recurrent UBE3C-LRP5 translocations in head and neck cancer with therapeutic implications

npj Precision Oncology
Head and neck cancer is a major cause of morbidity and mortality worldwide. The identification of genetic alterations in head and neck cancer may improve diagnosis and treatment outcomes.
Bhasker Dharavath, Ashwin Butle, Akshita Chaudhary, Ankita Pal, Sanket Desai, Aniket Chowdhury, Rahul Thorat, Pawan Upadhyay, Sudhir Nair, Amit Dutt   +9 more
doaj   +1 more source

Progenetix: 12 years of oncogenomic data curation [PDF]

arXiv, 2013
DNA copy number aberrations (CNAs) can be found in the majority of cancer genomes, and are crucial for understanding the potential mechanisms underlying tumor initiation and progression. Since the first release in 2001, the Progenetix project (http://www.progenetix.org) has provided a reference resource dedicated to provide the most comprehensive ...
arxiv  

Genetic changes in breast cancer detected by comparative genomic hybridisation [PDF]

, 2000
Ruth L. Loveday, John Greenman, Deborah L. Simcox, Valerie Speirs, Philip Drew, John R.T. Monson, Michael J. Kerin   +6 more
openalex   +1 more source

Prognostic value of genomic alterations in minimal residual cancer cells purified from the blood of breast cancer patients [PDF]

, 2000
F Austrup, Peter Uciechowski, C Eder, Beatrix Böckmann, Bernhard Suchy, G. Driesel, Sven Jäckel, I. Kusiak, H-J Grill, M. Giesing   +9 more
openalex   +1 more source

Mapping of Target Regions of Allelic Loss in Primary Breast Cancers to 1‐cM Intervals on Genomic Contigs at 6q21 and 6q25.3 [PDF]

, 2000
Yoshihito Utada, Shunsuke Haga, Tetsuro Kajiwara, Fujio Kasumi, Goi Sakamoto, Yusuke Nakamura, Mitsuru Emi   +6 more
openalex   +1 more source

DNA Ploidy and Chromosomal Imbalances in Invasive Ductal Breast Cancer. A Comparative Study of DNA Image Cytometry and Comparative Genomic Hybridization (CGH) [PDF]

, 2000
Katrin Friedrich, Jens Scheithauer, V. Dimmer, W. Meyer, F Theissig, G. Haroske, Klaus Dietmar Kunze   +6 more
openalex   +1 more source

Are tumor-associated carbohydrates the missing link between the gut microbiome and response to immune checkpoint inhibitor treatment in cancer?

OncoImmunology
Immune checkpoint inhibitor therapy has dramatically improved survival in a significant subset of patients with several solid tumor types. Increasing the number of patients benefitting from this form of therapy is an important translational research goal.
Zoltan Szallasi, Aurel Prosz, Zsofia Sztupinszki, Judit Moldvay   +3 more
doaj   +1 more source

The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality

Molecular Systems Biology, 2014
Variable screen quality, off‐target effects, and unclear false discovery rates often hamper large‐scale functional genomic screens in mammalian cells. Hart et al (2014) introduce gold standard reference sets of essential and non‐essential genes, aiming ...
Bastiaan Evers, Rene Bernards, Roderick L Beijersbergen   +2 more
doaj   +1 more source