Results 121 to 130 of about 274,173 (312)

Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Nature Communications
The chromosome 5p15.33 region, which encodes telomerase reverse transcriptase (TERT), harbors multiple germline variants identified by genome-wide association studies (GWAS) as risk for some cancers but protective for others.
Oscar Florez-Vargas, Michelle Ho, Maxwell H. Hogshead, Brenen W. Papenberg, Chia-Han Lee, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberley J. Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, Chi Zhang, John S. Schneekloth, Mitchell J. Machiela, Stephen J. Chanock, Shahinaz M. Gadalla, Sharon A. Savage, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson   +22 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

, 2018
Youqiong Ye, Yu Xiang, Fatma Muge Ozguc, Yoon-Jin Kim, Chunjie Liu, Peter K. Park, Qingsong Hu, Lixia Diao, Yanyan Lou, Chunru Lin, An‐Yuan Guo, Bingying Zhou, Li Wang, Zheng Chen, Joseph S. Takahashi, Gordon B. Mills, Seung Hee Yoo, Leng Han   +17 more
openalex   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The inner nuclear membrane protein, Banf1, has an essential role in triple negative breast cancer cell proliferation and survival

Scientific Reports
Triple negative breast cancers (TNBCs) are a heterogenous subcategory of breast cancers which have significantly worse survival outcomes compared to other breast cancer subtypes.
Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Iain Richard, Amila Suraweera, Mark N. Adams, Pascal H. G. Duijf, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson   +9 more
doaj   +1 more source

Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes [PDF]

, 2022
Alessandro Di Federico, Andrea De Giglio, Francesco Gelsomino, Dario de Biase, Francesca Giunchi, Arianna Palladini, Francesca Sperandi, Barbara Melotti, Andrea Ardizzoni   +8 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Imaging genomics of cancer: a bibliometric analysis and review

Cancer Imaging
Background Imaging genomics is a burgeoning field that seeks to connections between medical imaging and genomic features. It has been widely applied to explore heterogeneity and predict responsiveness and disease progression in cancer.
Xinyi Gou, Aobo Feng, Caizhen Feng, Jin Cheng, Nan Hong   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The tandem duplicator phenotype as a distinct genomic configuration in cancer [PDF]

, 2016
Francesca Menghi, Koichiro Inaki, Xingyi Woo, Pooja Kumar, Krzysztof R. Grzȩda, Ankit Malhotra, Vinod Kumar Yadav, Hyunsoo Kim, Eladio J. Márquez, Duygu Ucar, Phung Trang Shreckengast, Joel P. Wagner, G. Macintyre, Krishna R. Murthy Karuturi, Ralph Scully, James Keck, Jeffrey H. Chuang, Edison T. Liu   +17 more
openalex   +1 more source