Results 131 to 140 of about 274,173 (312)
PP121 Comparison of genomic and transcriptional homologous recombination deficiency assays in breast cancer patients with germline BRCA mutations
, 2022 H. Chae, S.H. Sim, Jae‐Hong Kim, W-J. Song, Y.J. Park, E-G. Lee, J.H. Han, S-Y. Jung, S. Lee, E.S. Lee, Yong‐Soon Kwon, K.S. Lee, S-Y. Kong +12 moreopenalex +1 more sourceAnalysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon [PDF]
, 2023 Guillem Pons, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Júlia Sansa-Girona, Lia García-Gilabert, Ainara Magdaleno, Miguel F. Segura, Joan Sánchez-de-Toledo, Soledad Gallego, Lucas Moreno, Josep Roma +11 moreopenalex +1 more sourceMonitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien +35 morewiley +1 more sourceSupplementary information from Genomic Landscape Established by Allelic Imbalance in the Cancerization Field of a Normal Appearing Airway
, 2023 Yasminka A. Jakubek, Wenhua Lang, Selina Vattathil, Melinda Garcia, Xu Li, Lili Huang, Suk‐Young Yoo, Li Shen, Wei Lu, Chi-Wan Chow, Zachary Weber, Gareth Davies, Jing Huang, Carmen Behrens, Neda Kalhor, César A. Moran, Junya Fujimoto, Reza J. Mehran, Randa El‐Zein, Stephen G. Swisher, Jing Wang, Jerry Fowler, Avrum Spira, Erik A. Ehli, Ignacio I. Wistuba, Paul Scheet, Humam Kadara +26 moreopenalex +1 more sourceTREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde +2 morewiley +1 more sourceLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceScreening of Germline BRCA1 and BRCA2 Variants in Nigerian Breast Cancer Patients
Technology in Cancer Research & TreatmentBackground Breast cancer remains a leading cause of mortality among Nigerian women, with triple-negative breast cancer (TNBC) being particularly prevalent. Variations in BRCA1 and BRCA2 genes remain key risk factors for this disease.Abimbola F. Onyia MSc, Paul Jibrin MBBS, Temitope Olatunji-Agunbiade MBBS, Ademola Oyekan MBBS, AbdulRazzaq Lawal MBBS, Adewumi Alabi MBBS, Anthonia C. Sowunmi MBBS, Eben A. Aje MBBS, Oluwabusayo B. Ogunniyi MBBS, Ebenezer S. Nkom MBBS, Opeyemi C. De Campos PhD, Oluwakemi A. Rotimi PhD, Jelili O. Oyelade PhD, Solomon O. Rotimi PhD +13 moredoaj +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more source
