Results 171 to 180 of about 274,173 (312)

Spotlight on cancer genomics [PDF]

Nature Cancer, 2020
openaire   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cancer genomics and bioinformatics in Latin American countries: applications, challenges, and perspectives. [PDF]

Front Oncol
Torres-Narvaez ES, Mendivelso-González DF, Artunduaga-Alvarado JA, Ortega-Recalde O.   +3 more
europepmc   +1 more source

The Crucial Findings Derived from the Special Issue "Inside Cancer Genomics: From Structure to Therapy". [PDF]

Cancers (Basel), 2023
Barresi V.
europepmc   +1 more source

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa [PDF]

, 2020
Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verne Vanderpuye, Mustapha Abubakar, Máire A. Duggan, Daniel G. Stover, Kofi Nyarko, John M. S. Bartlet, Francis Aitpillah, Daniel Ansong, Kevin Gardner, Felix Andy Boateng, A. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe‐Addai, Montserrat García‐Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak   +30 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Correction: Virtual Cancer Genomics: An Accessible and Effective Approach to Research Training for Undergraduates. [PDF]

J Cancer Educ
Gerace EL, Wojiski S.
europepmc   +1 more source

EXPANSION: a webserver to explore the functional consequences of protein-coding alternative splice variants in cancer genomics. [PDF]

Bioinform Adv, 2023
Arora C, De Oliveira Rosa N, Matic M, Cascone M, Miglionico P, Raimondi F.   +5 more
europepmc   +1 more source

Clinical use of the Oncotype DX genomic test to guide treatment decisions for patients with invasive breast cancer

, 2017
Terri McVeigh, Michael J. Kerin
openalex   +2 more sources

Integrative Genomics Analysis Reveals Silencing of β-Adrenergic Signaling by Polycomb in Prostate Cancer [PDF]

, 2007
Jindan Yu, Qi Cao, Rohit Mehra, Bharathi Laxman, Jianjun Yu, Scott A. Tomlins, Chad J. Creighton, Saravana M. Dhanasekaran, Ronglai Shen, Guoan Chen, David S. Morris, Víctor E. Márquez, Rajal B. Shah, Debashis Ghosh, Sooryanarayana Varambally, Arul M. Chinnaiyan   +15 more
openalex   +1 more source