Results 21 to 30 of about 260,681 (237)
Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours
BMC Research Notes, 2020 Objective Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of
Sally M. Hunter +10 more
doaj +1 more source
Regulation of 3D Organization and Its Role in Cancer Biology
Frontiers in Cell and Developmental Biology, 2022 Three-dimensional (3D) genomics is the frontier field in the post-genomics era, its foremost content is the relationship between chromatin spatial conformation and regulation of gene transcription.
Anghui Peng +8 more
doaj +1 more source
Genomic and epigenomic integrative subtypes of renal cell carcinoma in a Japanese cohort
Nature Communications, 2023 Renal cell carcinoma (RCC) comprises several histological types characterised by different genomic and epigenomic aberrations; however, the molecular pathogenesis of each type still requires further exploration.
Akihiko Fukagawa +10 more
doaj +1 more source
Contextualization of drug-mediator relations using evidence networks
BMC Bioinformatics, 2017 Background Genomic analysis of drug response can provide unique insights into therapies that can be used to match the “right drug to the right patient.” However, the process of discovering such therapeutic insights using genomic data is not ...
Hai Joey Tran +3 more
doaj +1 more source
Genomics of Prostate Cancer: Clinical Utility and Challenges
Acta Clinica Croatica, 2022 The studying of prostate cancer genomics is important for understanding prostate cancer biology, it can provide clinically relevant stratification into subtypes, the development of new prognostic and predictive markers in the context of precision ...
Ivan Šamija, Ana Fröbe
doaj +1 more source
Scientific Reports, 2022 This review aimed to examine the relationship between TP53 mutational status, as determined by genomic sequencing, and survival in squamous cell carcinoma of the head and neck.
Shadi Basyuni +11 more
doaj +1 more source
Cancer-inspired Genomics Mapper Model for the Generation of Synthetic DNA Sequences with Desired Genomics Signatures [PDF]
, 2023 Genome data are crucial in modern medicine, offering significant potential for diagnosis and treatment. Thanks to technological advancements, many millions of healthy and diseased genomes have already been sequenced; however, obtaining the most suitable data for a specific study, and specifically for validation studies, remains challenging with respect
arxiv +1 more source
Integrated genetic and epigenetic analysis of myxofibrosarcoma
Nature Communications, 2018 Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of ...
Koichi Ogura +14 more
doaj +1 more source
Genomic sequencing in cancer [PDF]
Cancer Letters, 2013 Genomic sequencing has provided critical insights into the etiology of both simple and complex diseases. The enormous reductions in cost for whole genome sequencing have allowed this technology to gain increasing use. Whole genome analysis has impacted research of complex diseases including cancer by allowing the systematic analysis of entire genomes ...
Musaffe Tuna, Christopher I. Amos
openaire +3 more sources
BMC Medical Genomics, 2018 Background Bladder cancer has numerous genomic features that are potentially actionable by targeted agents. Nevertheless, both pre-clinical and clinical research using molecular targeted agents have been very limited in bladder cancer. Results We created
Adnan Ahmad Ansari +5 more
doaj +1 more source