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Application of Cancer Genomics to Solve Unmet Clinical Needs [PDF]
Genomics & Informatics, 2013 The large amount of data on cancer genome research has contributed to our understanding of cancer biology. Indeed, the genomics approach has a strong advantage for analyzing multi-factorial and complicated problems, such as cancer.
Se-Hoon Lee +4 more
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Cancer Genome Landscapes [PDF]
Science, 2013 Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of “hills” (genes altered infrequently). To date, these studies have revealed
Bert, Vogelstein +5 more
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Nature, 2009 All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving into an era in which it will be possible to obtain the complete DNA sequence of ...
Michael R, Stratton +2 more
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Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours
BMC Research Notes, 2020 Objective Ovarian fibromas and adenofibromas are rare ovarian tumours. They are benign tumours composed of spindle-like stromal cells (pure fibroma) or a mixture of fibroblast and epithelial components (adenofibroma). We have previously shown that 40% of
Sally M. Hunter +10 more
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Improved methods for RNAseq-based alternative splicing analysis
Scientific Reports, 2021 The robust detection of disease-associated splice events from RNAseq data is challenging due to the potential confounding effect of gene expression levels and the often limited number of patients with relevant RNAseq data.
Rebecca F. Halperin +13 more
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Nature, 2001 Identification of the genes that cause oncogenesis is a central aim of cancer research. We searched the proteins predicted from the draft human genome sequence for paralogues of known tumour suppressor genes, but no novel genes were identified. We then assessed whether it was possible to search directly for oncogenic sequence changes in cancer cells by
P A, Futreal +5 more
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Research and Progress of Artificial Intelligence in the Imaging Genomics of Lung Cancer
Taiyuan Ligong Daxue xuebao, 2022 Imaging genomics based on artificial intelligence technology has shown great potential in personalized treatment and precision medicine, providing important theoretical basis and technical support for the intelligent diagnosis and prognosis prediction of
Liye JIA +4 more
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F1000Research, 2015 Modern cancer genomics has emerged from the combination of the Human Genome Reference, massively parallel sequencing, and the comparison of tumor to normal DNA sequences, revealing novel insights into the cancer genome and its amazing diversity. Recent developments in applying our knowledge of cancer genomics have focused on the utility of these data ...
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Regulation of 3D Organization and Its Role in Cancer Biology
Frontiers in Cell and Developmental Biology, 2022 Three-dimensional (3D) genomics is the frontier field in the post-genomics era, its foremost content is the relationship between chromatin spatial conformation and regulation of gene transcription.
Anghui Peng +8 more
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Functional Genomic Characterization of Cancer Genomes [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2016 International efforts to sequence cancer genomes now provide an overview of the major genetic alterations that occur in most human cancers. These studies have identified many highly recurrent alterations in specific cancer subtypes but have also identified mutations that occur at lower frequency and unstudied variants of known cancer-associated genes ...
Thomas P, Howard +7 more
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