Results 331 to 340 of about 5,135,152 (380)
Some of the next articles are maybe not open access.
Urologia Journal, 2020
Until recently, the treatment of bladder cancer, for several years, was limited to surgery and to immunotherapy or chemotherapy. Currently, the extensive analysis of molecular alterations has led to novel treatment approaches. The advent of polymerase chain reaction and genomic hybridization techniques has allowed to investigate alterations involved ...
Siracusano, Salvatore +2 more
openaire +5 more sources
Until recently, the treatment of bladder cancer, for several years, was limited to surgery and to immunotherapy or chemotherapy. Currently, the extensive analysis of molecular alterations has led to novel treatment approaches. The advent of polymerase chain reaction and genomic hybridization techniques has allowed to investigate alterations involved ...
Siracusano, Salvatore +2 more
openaire +5 more sources
The cancer genomics and global cancer genome collaboration
Chinese Science Bulletin, 2015All cancers arise as a result of abnormalities occurring in the DNA sequence of cancer cells, and we are now stepping into an era in which it is feasible to obtain the complete DNA sequence of large cohorts of cancer patients. The International Cancer Genome Consortium (ICGC) launched in 2007 is devoted to coordinate large-scale cancer genome studies ...
Xueda Hu +3 more
openaire +2 more sources
Current Opinion in Oncology, 2002
Genetic and environmental factors are responsible for the genomic lesions that cause cancer, a complex genetic disease associated with genomic instability. Studies aimed at deciphering the lesions in cancer have focused mainly on one or a few genes, despite the genomic scope of the disease.
openaire +3 more sources
Genetic and environmental factors are responsible for the genomic lesions that cause cancer, a complex genetic disease associated with genomic instability. Studies aimed at deciphering the lesions in cancer have focused mainly on one or a few genes, despite the genomic scope of the disease.
openaire +3 more sources
Current Opinion in Genetics & Development, 2014
Pancreatic cancer is one of the most lethal malignancies. The overall median survival even with treatment is only 6-9 months, with almost 90% succumbing to the disease within a year of diagnosis. It is characterised by an intense desmoplastic stroma that may contribute to therapeutic resistance, and poses significant challenges for genomic sequencing ...
Andrew V. Biankin +3 more
openaire +4 more sources
Pancreatic cancer is one of the most lethal malignancies. The overall median survival even with treatment is only 6-9 months, with almost 90% succumbing to the disease within a year of diagnosis. It is characterised by an intense desmoplastic stroma that may contribute to therapeutic resistance, and poses significant challenges for genomic sequencing ...
Andrew V. Biankin +3 more
openaire +4 more sources
Genomic Instability and Cancer
Current Molecular Medicine, 2003Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities.
George S. Charames, Bharati Bapat
openaire +2 more sources
Annual Review of Genomics and Human Genetics, 2010
Cancer profiling studies have had a profound impact on our understanding of the biology of cancers in a number of ways, including providing insights into the biological heterogeneity of specific cancer types, identification of novel oncogenes and tumor suppressors, and defining pathways that interact to drive the growth of individual cancers.
Prue A. Cowin +3 more
openaire +3 more sources
Cancer profiling studies have had a profound impact on our understanding of the biology of cancers in a number of ways, including providing insights into the biological heterogeneity of specific cancer types, identification of novel oncogenes and tumor suppressors, and defining pathways that interact to drive the growth of individual cancers.
Prue A. Cowin +3 more
openaire +3 more sources
Experimental Cell Research, 1999
Fifteen years have gone by since the initial demonstrations of mammalian genomic imprinting (Barton et al. 1984; McGrath andSolter 1984; Surani et al. 1984), 7 years since the identification of specific imprinted genes in mice (DeChiara et al. 1991; Barlow et al. 1991; Bartolomei et al.
openaire +6 more sources
Fifteen years have gone by since the initial demonstrations of mammalian genomic imprinting (Barton et al. 1984; McGrath andSolter 1984; Surani et al. 1984), 7 years since the identification of specific imprinted genes in mice (DeChiara et al. 1991; Barlow et al. 1991; Bartolomei et al.
openaire +6 more sources
Genomics and proteomics in cancer
European Journal of Cancer, 2003Cancer development is driven by the accumulation of DNA changes in the approximately 40000 chromosomal genes. In solid tumours, chromosomal numerical/structural aberrations are common. DNA repair defects may lead to genome-wide genetic instability, which can drive further cancer progression.
Jan P. A. Baak +5 more
openaire +3 more sources
The genetics and genomics of cancer
Nature Genetics, 2003The past decade has seen great strides in our understanding of the genetic basis of human disease. Arguably, the most profound impact has been in the area of cancer genetics, where the explosion of genomic sequence and molecular profiling data has illustrated the complexity of human malignancies.
Joe W. Gray +2 more
openaire +3 more sources
Proceedings of the 17th ACM SIGKDD international conference on Knowledge discovery and data mining, 2011
Throughout life, the cells in every individual accumulate many changes in the DNA inherited from his or her parents. Certain combinations of changes lead to cancer. During the last decade, the cost of DNA sequencing has been dropping by a factor of 10 every two years, making it now possible to read most of the three billion base genome from a patient's
openaire +2 more sources
Throughout life, the cells in every individual accumulate many changes in the DNA inherited from his or her parents. Certain combinations of changes lead to cancer. During the last decade, the cost of DNA sequencing has been dropping by a factor of 10 every two years, making it now possible to read most of the three billion base genome from a patient's
openaire +2 more sources