Results 341 to 350 of about 5,135,152 (380)
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Nature Reviews Drug Discovery, 2013
A recent landmark analysis compared genome-wide mutations and associated 'omics' features for 3,281 tumours across 12 human cancer types. There is a clear need for objective target assessment and prioritization by the drug discovery community to make the best use of such vast amounts of data.
Paul Workman, Bissan Al-Lazikani
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A recent landmark analysis compared genome-wide mutations and associated 'omics' features for 3,281 tumours across 12 human cancer types. There is a clear need for objective target assessment and prioritization by the drug discovery community to make the best use of such vast amounts of data.
Paul Workman, Bissan Al-Lazikani
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Environment, genome and cancer
Comptes Rendus de l'Académie des Sciences - Series III - Sciences de la Vie, 2001Cancer is one of the most serious diseases that threaten human being today. To some degree, it is a genetic disease but environmental and other nongenetic factors clearly play a role in many stages of neoplastic process. Genetic factors by themselves are thought to explain only about 5% of all cancer.
Sai-Juan Chen, Lu Wang
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Current Urology Reports, 2001
The molecular processes contributing to cancer of the human prostate gland are under intensive investigation. Methods used for discovering genetic alterations involved in prostate neoplasia include family studies designed to map hereditary disease loci, chromosomal studies to identify aberrations that may locate oncogenes or tumor suppressor genes, and
Paul E. Li, Peter S. Nelson
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The molecular processes contributing to cancer of the human prostate gland are under intensive investigation. Methods used for discovering genetic alterations involved in prostate neoplasia include family studies designed to map hereditary disease loci, chromosomal studies to identify aberrations that may locate oncogenes or tumor suppressor genes, and
Paul E. Li, Peter S. Nelson
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Bioinformatics and Systems Biology, 2018
The cBioPortal for Cancer Genomics is an open source software platform that enables interactive, exploratory analysis of large-scale cancer genomics data sets.
Jianjiong Gao +36 more
semanticscholar +1 more source
The cBioPortal for Cancer Genomics is an open source software platform that enables interactive, exploratory analysis of large-scale cancer genomics data sets.
Jianjiong Gao +36 more
semanticscholar +1 more source
2012
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with the worst prognosis among all solid tumors [1]. Although surgical resection offers the only hope for cure, it is possible in only 20% of patients that present with local disease [2]. Indeed, most patients are diagnosed at an advanced stage, when the disease is inoperable.
CORBO, Vincenzo +3 more
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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with the worst prognosis among all solid tumors [1]. Although surgical resection offers the only hope for cure, it is possible in only 20% of patients that present with local disease [2]. Indeed, most patients are diagnosed at an advanced stage, when the disease is inoperable.
CORBO, Vincenzo +3 more
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Cancer Genomics: Diversity and Disparity Across Ethnicity and Geography.
Journal of Clinical Oncology, 2016Ethnic and geographic differences in cancer incidence, prognosis, and treatment outcomes can be attributed to diversity in the inherited (germline) and somatic genome.
D. Tan, T. Mok, T. Rebbeck
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Current Opinion in Genetics & Development, 2008
Cancer genomics has focused on the discovery of genetic mutations and chromosomal structural rearrangements that either increase susceptibility to cancer or support the cancer phenotype. Though each individual mutation may induce specific cancer phenotypes, it is the interaction of the functional changes in transcription and proteins that give the ...
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Cancer genomics has focused on the discovery of genetic mutations and chromosomal structural rearrangements that either increase susceptibility to cancer or support the cancer phenotype. Though each individual mutation may induce specific cancer phenotypes, it is the interaction of the functional changes in transcription and proteins that give the ...
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Abstract 2584: The UCSC Xena system for cancer genomics data visualization and interpretation
, 2017The UCSC Xena platform (http://xena.ucsc.edu/) allows biologists and bioinformaticians to securely analyze and visualize their private functional genomics data in the context of public genomic and clinical data sets.
M. Goldman +3 more
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Cancer Genomics and Important Oncologic Mutations: A Contemporary Guide for Body Imagers.
Radiology, 2017The field of cancer genomics is rapidly evolving and has led to the development of new therapies. Knowledge of commonly involved cellular pathways and genetic mutations is now essential for radiologists reading oncology cases.
V. Cox +9 more
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