Results 31 to 40 of about 260,681 (237)
Cancer Genome Landscapes [PDF]
Science, 2013 Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of “hills” (genes altered infrequently). To date, these studies have revealed
Kenneth W. Kinzler +5 more
openaire +3 more sources
Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans [PDF]
Genomics & Informatics, 2012 Gastric cancer is ranked as the most common cancer in Koreans. A recent molecular biological study about the folate pathway gene revealed the correlation with a couple of cancer types.
Jae-Young Yoo +6 more
doaj +1 more source
Factor Models for Cancer Signatures [PDF]
Physica A 462 (2016) 527-559, 2016 We present a novel method for extracting cancer signatures by applying statistical risk models (http://ssrn.com/abstract=2732453) from quantitative finance to cancer genome data. Using 1389 whole genome sequenced samples from 14 cancers, we identify an "overall" mode of somatic mutational noise.
arxiv +1 more source
Genomic Instability in Cancer [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 One of the fundamental challenges facing the cell is to accurately copy its genetic material to daughter cells. When this process goes awry, genomic instability ensues in which genetic alterations ranging from nucleotide changes to chromosomal translocations and aneuploidy occur.
Tarek Abbas +3 more
openaire +3 more sources
Selective therapeutic strategy for p53-deficient cancer by targeting dysregulation in DNA repair
Communications Biology, 2021 Zonneville et al. show that p53 mutant cancers express high levels of the Base Excision Repair (BER) pathway and that deoxyuridine analogues induce DNA damage in p53-mutant TNBC cells.
Justin Zonneville +10 more
doaj +1 more source
Genomic imprinting and cancer [PDF]
Molecular Pathology, 1998 Genomic imprinting is the phenomenon by which individual alleles of certain genes are expressed differentially according to their parent of origin. The alleles appear to be differentially marked during gametogenesis or during the early part of development. This mark is heritable but reversible from generation to generation, implying a stable epigenetic
P N Schofield, J A Joyce
openaire +2 more sources
Translational Oncology, 2014 The National Cancer Institute (NCI) Cancer Imaging Program organized two related workshops on June 26–27, 2013, entitled “Correlating Imaging Phenotypes with Genomics Signatures Research” and “Scalable Computational Resources as Required for Imaging ...
Rivka Colen +15 more
doaj +1 more source
Understanding genomic alterations in cancer genomes using an integrative network approach [PDF]
, 2014 In recent years, cancer genome sequencing and other high-throughput studies of cancer genomes have generated many notable discoveries. In this review, Novel genomic alteration mechanisms, such as chromothripsis (chromosomal crisis) and kataegis (mutation storms), and their implications for cancer are discussed.
arxiv +1 more source
A Clustering Approach to Integrative Analysis of Multiomic Cancer Data [PDF]
arXiv, 2022 Rapid technological advances have allowed for molecular profiling across multiple omics domains from a single sample for clinical decision making in many diseases, especially cancer. As tumor development and progression are dynamic biological processes involving composite genomic aberrations, key challenges are to effectively assimilate information ...
arxiv
Massively parallel digital transcriptional profiling of single cells
Nature Communications, 2017 Single-cell gene expression analysis is challenging. This work describes a new droplet-based single cell RNA-seq platform capable of processing tens of thousands of cells across 8 independent samples in minutes, and demonstrates cellular subtypes and ...
Grace X. Y. Zheng +32 more
doaj +1 more source