Results 41 to 50 of about 260,681 (237)
Predictive genomics: A cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing data [PDF]
, 2014 We discuss a cancer hallmark network framework for modelling genome-sequencing data to predict cancer clonal evolution and associated clinical phenotypes. Strategies of using this framework in conjunction with genome sequencing data in an attempt to predict personalized drug targets, drug resistance, and metastasis for a cancer patient, as well as ...
arxiv +1 more source
Acta Medica Academica, 2019 <p>The landscape of lung cancer treatment is rapidly evolving with the use of genomic testing which helps identify specific mutations or resistance mutations for these heterogenous tumors. Advanced lung cancer has a very poor prognosis but identifying other treatment options based on genomic profiling of the tumor can lead to improved outcomes ...
openaire +3 more sources
VGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
Scientific Reports, 2017 Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety of environmental cues.
Yinglong Zhang +10 more
doaj +1 more source
Data Mining Supercomputing with SAS JMP® Genomics [PDF]
Journal of Systemics, Cybernetics and Informatics, 2011 JMP® Genomics is statistical discovery software that can uncover meaningful patterns in high-throughput genomics and proteomics data. JMP® Genomics is designed for biologists, biostatisticians, statistical geneticists, and those engaged in analyzing the ...
Richard S. Segall +2 more
doaj
Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas
Nature Communications, 2018 Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient
S. R. Rosario +5 more
doaj +1 more source
Journal of Thoracic Disease, 2017 Multi-platform investigation of non-small cell lung cancer has the capability of discovering clinically important biological pathways involved in cancer development, progression, prognosis and response to treatment in patients with lung cancer. These two complementary publications from this productive research group describe genomic analyses of the two
Fong, Kwun M. +2 more
openaire +4 more sources
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt
mSphere, 2021 Infection by multidrug-resistant (MDR) Acinetobacter baumannii is one of the major causes of hospital-acquired infections worldwide. The ability of A. baumannii to survive in adverse conditions as well as its extensive antimicrobial resistance make it ...
Deena Jalal +9 more
doaj +1 more source
Hypersensitivity to DNA damage in antephase as a safeguard for genome stability
Nature Communications, 2016 The DNA damage response induces a reversible arrest at different cell cycle stages. Here the authors find that loss of the APC/C inhibitor Emi1 in antephase (late G2) results in hypersensitivity to DNA damage and cell cycle exit at DNA damage levels that
Femke M. Feringa +6 more
doaj +1 more source
The genomics of brain cancer [PDF]
Nature, 2018 A flood of sequencing data is enabling researchers to uncover how tumours differ from each other, and what such variation means for treatment strategies. A flood of sequencing data is enabling researchers to uncover how tumours differ from each other, and what such variation means for treatment strategies.
openaire +3 more sources
Genomic Instability and Cancer [PDF]
Journal of Carcinogenesis & Mutagenesis, 2014 Genomic instability is a characteristic of most cancer cells. It is an increased tendency of genome alteration during cell division. Cancer frequently results from damage to multiple genes controlling cell division and tumor suppressors. It is known that genomic integrity is closely monitored by several surveillance mechanisms, DNA damage checkpoint ...
Wei Dai, Yixin Yao
openaire +3 more sources