Results 51 to 60 of about 260,681 (237)

Computational methods for cancer driver discovery: A survey [PDF]

arXiv, 2020
Motivation: Uncovering the genomic causes of cancer, known as cancer driver genes, is a fundamental task in biomedical research. Cancer driver genes drive the development and progression of cancer, thus identifying cancer driver genes and their regulatory mechanism is crucial to the design of cancer treatment and intervention.
arxiv  

Cancer systems biology in the genome sequencing era: Part 1, dissecting and modeling of tumor clones and their networks [PDF]

, 2014
Recent tumor genome sequencing confirmed that one tumor often consists of multiple cell subpopulations (clones) which bear different, but related, genetic profiles such as mutation and copy number variation profiles. Thus far, one tumor has been viewed as a whole entity in cancer functional studies.
arxiv   +1 more source

Review of State Comprehensive Cancer Control Plans for Genomics Content

Preventing Chronic Disease, 2005
Introduction The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives.
Robert C. Millikan, DVM, PhD, Tejinder Rakhra-Burris, MA, Erin Shaughnessy Zuiker, MPH, Debra E. Irwin, PhD, MSPH   +3 more
doaj  

A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency

BMC Genomics
Genome-wide CRISPR sgRNA libraries have emerged as transformative tools to systematically probe gene function. While these libraries have been iterated over time to be more efficient, their large size limits their use in some applications.
Sebastian Lukasiak, Alex Kalinka, Nikhil Gupta, Angelos Papadopoulos, Khalid Saeed, Ultan McDermott, Gregory James Hannon, Douglas Ross-Thriepland, David Walter   +8 more
doaj   +1 more source

Functional Genomic Characterization of Cancer Genomes [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2016
International efforts to sequence cancer genomes now provide an overview of the major genetic alterations that occur in most human cancers. These studies have identified many highly recurrent alterations in specific cancer subtypes but have also identified mutations that occur at lower frequency and unstudied variants of known cancer-associated genes ...
Francisca Vazquez, Francisca Vazquez, William C. Hahn, William C. Hahn, Andrew L. Hong, Andrew L. Hong, Andrew L. Hong, Thomas P. Howard, Jesse S. Boehm, Mik Rinne, Mik Rinne, Aviad Tsherniak, Andrew J. Aguirre, Andrew J. Aguirre   +13 more
openaire   +2 more sources

Somatic Tumor Mutations Detected by Targeted Next Generation Sequencing in Minute Amounts of Serum-Derived Cell-Free DNA

Scientific Reports, 2017
The use of blood-circulating cell-free DNA (cfDNA) as ‘liquid-biopsy’ is explored worldwide, with hopes for its potential in providing prognostic or predictive information in cancer treatment.
Marjolein J. A. Weerts, Ronald van Marion, Jean C. A. Helmijr, Corine M. Beaufort, Niels M. G. Krol, Anita M. A. C. Trapman-Jansen, Winand N. M. Dinjens, Stefan Sleijfer, Maurice P. H. M. Jansen, John W. M. Martens   +9 more
doaj   +1 more source

The Global Cancer Genomics Consortium: Interfacing Genomics and Cancer Medicine [PDF]

Cancer Research, 2012
Abstract The Global Cancer Genomics Consortium (GCGC) is an international collaborative platform that amalgamates cancer biologists, cutting-edge genomics, and high-throughput expertise with medical oncologists and surgical oncologists; they address the most important translational questions that are central to cancer research and ...
M. Radhakrishna Pillai, Stefan Knapp, Sudeep Gupta, Luis Costa, Masakazu Toi, Amit Dutt, Rajandra A Badwe, Rakesh Kumar, Jeyanthy Eswaran   +8 more
openaire   +2 more sources

Pilot clinical trial and phenotypic analysis in chemotherapy-pretreated, metastatic triple-negative breast cancer patients treated with oral TAK-228 and TAK-117 (PIKTOR) to increase DNA damage repair deficiency followed by cisplatin and nab paclitaxel

Biomarker Research, 2023
Background A subset of triple-negative breast cancers (TNBCs) have homologous recombination deficiency with upregulation of compensatory DNA repair pathways.
Jessica D. Lang, Tuong Vi V. Nguyen, Maren K. Levin, Page E. Blas, Heather L. Williams, Esther San Roman Rodriguez, Natalia Briones, Claudius Mueller, William Selleck, Sarah Moore, Victoria L. Zismann, William P.D. Hendricks, Virginia Espina, Joyce O’Shaughnessy   +13 more
doaj   +1 more source

CIBRA identifies genomic alterations with a system-wide impact on tumor biology [PDF]

Bioinformatics, Volume 40, Issue Supplement 2, September 2024, Pages ii37-ii44
Background: Genomic instability is a hallmark of cancer, leading to many somatic alterations. Identifying which alterations have a system-wide impact is a challenging task. Nevertheless, this is an essential first step for prioritizing potential biomarkers. We developed CIBRA (Computational Identification of Biologically Relevant Alterations), a method
arxiv   +1 more source

The genomic landscape of prostate cancer [PDF]

Frontiers in Endocrinology, 2012
Prostate cancer is a common malignancy in men, with a markedly variable clinical course. Somatic alterations in DNA drive the growth of prostate cancers and may underlie the behavior of aggressive versus indolent tumors. The accelerating application of genomic technologies over the last two decades has identified mutations that drive prostate cancer ...
Sylvan eBaca, Sylvan eBaca, Sylvan eBaca, Levi A. Garraway, Levi A. Garraway, Levi A. Garraway, Levi A. Garraway   +6 more
openaire   +5 more sources