Results 71 to 80 of about 260,681 (237)
BMC Cancer, 2019 Background While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%.
Sarah Weber +8 more
doaj +1 more source
Addressing Ancestry Disparities in Genomic Medicine: A Geographic-aware Algorithm [PDF]
arXiv, 2020 With declining sequencing costs a promising and affordable tool is emerging in cancer diagnostics: genomics. By using association studies, genomic variants that predispose patients to specific cancers can be identified, while by using tumor genomics cancer types can be characterized for targeted treatment.
arxiv
A Common Gene Expression Signature Analysis Method for Multiple Types of Cancer [PDF]
2019 19th Industrial Conference on Data Mining, 2019 Mining gene expression profiles has proven valuable for identifying signatures serving as surrogates of cancer phenotypes. However, the similarities of such signatures across different cancer types have not been strong enough to conclude that they represent a universal biological mechanism shared among multiple cancer types.
arxiv
Rare Tumors, 2013 Sarcomas are cancers that arise in soft tissues or bone and make up a small percentage of malignancies. In an effort to identify potential genetic targets for therapy, this study explores the genomic landscape of a metastatic undifferentiated pleomorphic
Paul Kurywchak +6 more
doaj +1 more source
High-order chromatin architecture determines the landscape of chromosomal alterations in cancer [PDF]
arXiv, 2011 The rapid growth of cancer genome structural information provides an opportunity for a better understanding of the mutational mechanisms of genomic alterations in cancer and the forces of selection that act upon them. Here we test the evidence for two major forces, spatial chromosome structure and purifying (or negative) selection, that shape the ...
arxiv
Translational genomics in cancer research: converting profiles into personalized cancer medicine
Cancer Biology & Medicine, 2013 Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of malignancy is studied at the scale of whole genomes. While the discipline has been successful with respect to identifying specific oncogenes and tumor suppressors ...
Lalit Patel +3 more
doaj +1 more source
Precision Therapeutic Biomarker Identification with Application to the Cancer Genome Project [PDF]
arXiv, 2017 Cancer cell lines have frequently been used to link drug sensitivity and resistance with genomic profiles. To capture genomic complexity in cancer, the Cancer Genome Project (CGP) (Garnett et al., 2012) screened 639 human tumor cell lines with 130 drugs ranging from known chemotherapeutic agents to experimental compounds. Questions of interest include:
arxiv
F1000Research, 2015 Modern cancer genomics has emerged from the combination of the Human Genome Reference, massively parallel sequencing, and the comparison of tumor to normal DNA sequences, revealing novel insights into the cancer genome and its amazing diversity. Recent developments in applying our knowledge of cancer genomics have focused on the utility of these data ...
openaire +4 more sources
Cancer Genomics and Molecular Diagnosis—The Nineteenth International Symposium of Sapporo Cancer Seminar [PDF]
, 1999 Manuel Perucho +2 more
openalex +1 more source
Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
Nature CommunicationsThe Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus increased the ...
Jasper Panten +15 more
doaj +1 more source