Toward an integrated map of genetic interactions in cancer cells
Molecular Systems Biology, 2018 Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation.
Benedikt Rauscher +5 more
doaj +1 more source
A method to reduce ancestry related germline false positives in tumor only somatic variant calling
BMC Medical Genomics, 2017 Background Significant clinical and research applications are driving large scale adoption of individualized tumor sequencing in cancer in order to identify tumors-specific mutations.
Rebecca F. Halperin +17 more
doaj +1 more source
Convolutional neural network models for cancer type prediction based on gene expression [PDF]
arXiv, 2019 Background Precise prediction of cancer types is vital for cancer diagnosis and therapy. Important cancer marker genes can be inferred through predictive model. Several studies have attempted to build machine learning models for this task however none has taken into consideration the effects of tissue of origin that can potentially bias the ...
arxiv
Comparison of genetic changes in schistosome-related transitional and squamous bladder cancers using comparative genomic hybridization [PDF]
, 2000 Michael Muscheck +7 more
openalex +1 more source
An exact method to compute a $p$-value for the beyond-pairwise correlations among cancer gene mutations [PDF]
arXiv, 2015 The increasing observation of mutual exclusivity correlations among cancer gene mutations is a key component for identifying driver events or pathways in cancer genome analysis. Here we report a rigorous statistical method to compute an exact $p$-value for the beyond-pairwise mutual exclusivity or co-occurrence relationships among cancer gene mutations
arxiv
Genomic instability-based transgenic models of prostate cancer [PDF]
, 2000 Christina Voelkel‐Johnson +10 more
openalex +1 more source
PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs
Cell Reports, 2015 Most BRAF (V600E) mutant melanomas are sensitive to selective BRAF inhibitors, but BRAF mutant colon cancers are intrinsically resistant to these drugs because of feedback activation of EGFR.
Anirudh Prahallad +11 more
doaj +1 more source
Cancer systems biology: exploring cancer-associated genes on cellular networks [PDF]
Cellular and Molecular Life Sciences (CMLS), 64:1752-1762, 2007, 2007 Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we describe the recent advances in studying cancer-associated genes from a systems biological point of view. The integration of known cancer genes onto protein and signaling networks
arxiv
Genetic Imbalances in Precursor Lesions of Endometrial Cancer Detected by Comparative Genomic Hybridization [PDF]
, 2000 Marion Kiechle +6 more
openalex +1 more source