Results 201 to 210 of about 970,429 (266)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Influence of MASLD and MAFLD on long-term extrahepatic cancer incidence and cancer mortality in regional Australia. [PDF]

Intern Med J
Vaz K, Kemp W, Majeed A, Lubel J, Magliano DJ, Glenister KM, Bourke L, Simmons D, Simmons D, Roberts SK.   +9 more
europepmc   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Endometrial cancer mortality and its trends in China from 2004-2021. [PDF]

BMC Cancer
Zhong Y, Ouyang H, Rao Q, Wang Y, Huang Q.   +4 more
europepmc   +1 more source

International trends in cancer mortality revisited: Japan's site-specific progress and remaining challenges until 2024. [PDF]

Jpn J Clin Oncol
Katanoda K, Tanaka H, Ito Y.
europepmc   +1 more source

Breast cancer mortality in Argentina, 1991-2023: a nationwide ecological study of spatiotemporal patterns and regional inequalities. [PDF]

Lancet Reg Health Am
Marcelo Isidro F, Daniel AL, Andrea L, Emma A, Hernán D, Sol FA, Edgardo DJ.   +6 more
europepmc   +1 more source

Preoperative resting heart rate and colorectal cancer mortality: a robust association, but causality remains unestablished. [PDF]

J Gastrointest Oncol
de Oliveira NPD, Bezerra de Souza DL.
europepmc   +1 more source

Impact of diabetes on breast cancer mortality in elderly female patients: A retrospective analysis (1999-2020). [PDF]

Medicine (Baltimore)
Bin Gulzar AH, Ratan P, Faizan A, Waqar K, Riaz A, Khaskheli FI, Brohi F, Khan AH, Zaka S, Shahid A, Ali BA, Bibi M, Ahmed MA, Cheema AAA.   +13 more
europepmc   +1 more source

Patterns of sex differences in cancer mortality in Colombia: a population-based analysis, 1980-2023. [PDF]

Lancet Reg Health Am
Espinosa O, Smith AD, Bejarano V, Puentes G, Pino LE, Wiesner C, de Vries E, Cardona AF, Friebel R.   +8 more
europepmc   +1 more source