Results 171 to 180 of about 22,534,193 (360)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Efficacy and safety of the integrated puncture method vs. the conventional puncture method in Peripherally Inserted Central Catheter placement for cancer patients

Frontiers in Surgery
ObjectiveThis study aims to assess the efficacy and safety of the integrated puncture method compared to the conventional puncture method in cancer patients undergoing PICC placement.MethodsThe retrospective analysis included 224 cancer patients who ...
Xinpeng Wang, Yong Yang, Yuanyuan Zheng, Jie Chen, Yanfen Shen   +4 more
doaj   +1 more source

Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates

, 2014
ObjectivesTo systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage.DesignSystematic review and meta-analysis.Participants4494 patients with prostate ...
Birch, B., Eardley, S., Lai, Lily, Lewith, G., Leydon, G., Prescott, P., Watts, S.   +6 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

The emotional states and associated behavioral responses (flexible‐adaptive behaviors vs. inflexible‐maladaptive behaviors) of cancer patients during the SARS‐CoV‐2 outbreak: A multi‐center cross‐sectional study in Italy

Cancer Medicine
Objective Distress during SARS‐CoV‐2 outbreak affected also cancer patients' well‐being. Aim of this study was to investigate patient' reactions and behavior (flexible‐adaptive vs. inflexible‐maladaptive) during the SARS‐CoV‐2 outbreak.
Giuseppe Deledda, Sara Poli, Matteo Giansante, Eleonora Geccherle, Giovanna Fantoni, Incoronata Romaniello, Farina Gabriella, Matteo Verzè, Fabrizio Nicolis, Stefania Gori   +9 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Isolation of rare circulating tumour cells in cancer patients by microchip technology

Nature, 2007
S. Nagrath, L. Sequist, S. Maheswaran, D. Bell, D. Irimia, L. Ulkus, Matthew R. Smith, E. Kwak, S. Digumarthy, A. Muzikansky, P. Ryan, U. Balis, R. Tompkins, D. Haber, M. Toner   +14 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Effects of Physical Exercise on Depression and Anxiety in Cancer Patients: A Systematic Review

Clinics and Practice
Background: Depression affects around 280 million people globally and is one of the main causes of disability. Among people with cancer, depression and anxiety affect 20–25%, significantly reducing quality of life, adherence to treatments, and survival ...
Giacomo Farì, Annatonia Fai, Francesco Quarta, Morena Pitruzzella, Cristiano Sconza, Matteo Luigi Giuseppe Leoni, Giustino Varrassi, Marco Filipponi, Giuseppe Rollo, Alessio Baricich, Andrea Bernetti   +10 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source