Results 71 to 80 of about 766,086 (315)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Isoliquiritigenin Inhibits Metastatic Breast Cancer Cell-induced Receptor Activator of Nuclear Factor Kappa-B Ligand/Osteoprotegerin Ratio in Human Osteoblastic Cells [PDF]

, 2015
Bone destruction induced by the metastasis of breast cancer cells is a frequent complication that is caused by the interaction between cancer cells and bone cells.
박광균, 이선경, 김현정, 정원윤   +3 more
core   +1 more source

Population-based Genetic Testing for Precision Prevention [PDF]

, 2020
Global interest in genetic-testing for Cancer-Susceptibility-Genes (CSG) has surged with falling costs, increasing awareness and celebrity endorsement.
Manchanda, R, Evans, O
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Global burden of lung cancer attributable to occupational asbestos exposure: 1990 to 2021

Environmental Health
Background Asbestos is a well-established occupational carcinogen, with strong evidence linking its exposure to lung cancer. Despite increasing awareness of its health risks, asbestos continues to be used in many countries.
Qiulin Huang, Yongran Cheng, Ruijiao Lei, Zijian Chen, Wei Gu, Kari Hemminki, Tianhui Chen   +6 more
doaj   +1 more source

Exposure to second-hand smoke at work in the European Union, 2006-2014

Tobacco Prevention and Cessation, 2018
Introduction Aim: After the classification of second-hand smoke (SHS) as a known human pulmonary carcinogen by International Agency for Research on Cancer, most Countries of the European Union (EU) introduced smoking ban at workplaces and public places ...
Barbara Cortini, Giulia Carreras, Simona Verdi, Elisabetta Chellini, Giuseppe Gorini   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Association between mukbang-watching (eating broadcasts) and depression in Korean adults

BMC Psychiatry
Background Mukbang is an online content genre where hosts eat large amounts of food while interacting with viewers. While earlier studies have suggested an association between mukbang viewing to obesity and disordered eating, its association with ...
Hyein Jung, Ahyoung Yun, Byungmi Kim, Yoonjoo Choi   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer

BMC Cancer, 2018
Background We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using a comprehensive multigene ...
Ji Soo Park, Seung-Tae Lee, Eun Ji Nam, Jung Woo Han, Jung-Yun Lee, Jieun Kim, Tae Il Kim, Hyung Seok Park   +7 more
doaj   +1 more source