Results 191 to 200 of about 1,781,442 (262)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Statins and postmenopausal breast cancer risk; results from the KARMA cohort. [PDF]

Cancer Causes Control
Klintman M, Rosendahl AH, Johannesen BR, Cronin-Fenton D, Eriksson M, Czene K, Hall P, Borgquist S.   +7 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Modifiable Lifestyle and Environmental Determinants of Ovarian Cancer Risk: Implications for Primary Prevention. [PDF]

Healthcare (Basel)
Arcieri M, Restaino S, Crivellaro N, Bogani G, Pregnolato S, Armenise D, Paparcura F, Bordin F, Filippin S, Pup LD, Driul L, Peccatori FA, Ronsini C, Cianci S, Stabile G, Perelli F, Capozzi VA, Berretta R, Vizzielli G, The Italian Women's Ovarian Health And Prevention Collaborative Group.   +19 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Cancer risk in patients with recurrent or persistent symptoms: a systematic review. [PDF]

Lancet Reg Health Eur
Dannhauser F, Calanzani N, Aslam A, Chang A, Vimarkant A, Majeed M, Walter FM, Zhou Y.   +7 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Mapping pesticide mixtures to cancer risk at the country scale with spatial exposomics. [PDF]

Nat Health
Honles J, Cerapio JP, Monge C, Marchio A, Ruiz E, Fernández R, Casavilca-Zambrano S, Contreras-Mancilla J, Vidaurre T, Condom T, Zerathe S, Dangles O, Deharo É, Herrera-Zuñiga J, Pineau P, Bertani S.   +15 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Vitamins and Cancer Risk: A Comprehensive Review of Epidemiologic and Clinical Evidence. [PDF]

Kans J Med
El Halabi L, AlBayeh A, Khoury A, Katrib M, Nasr J, Al-Obaidi A.   +5 more
europepmc   +1 more source