Results 141 to 150 of about 7,457,740 (401)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Endoscopic screening for esophageal squamous cell carcinoma [PDF]

, 2013
Esophageal cancer (EC) is the eighth common cancer and the sixth most common cause of death from cancer worldwide. Esophageal squamous cell carcinoma (ESCC) remains the most common type of EC in the developing world and an important health problem in ...
Amiriani, T., Khoshnia, M., Merat, S., Nouroozi, A., Pourshams, A., Roshandel, G., Semnani, S.   +6 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Global Trajectories of Colorectal Cancer Burden From 1990 to 2021 and Projection to 2040

Cancer Innovation
Background There is significant heterogeneity in patterns of colorectal cancer burden, which is still not well understood. This study examines global trajectories in the colorectal cancer burden, explores associated factors, and predicts future trends ...
Xiaolu Chen, Xuesi Dong, Yadi Zheng, Chenran Wang, Zilin Luo, Jiaxin Xie, Zeming Guo, Xiaoyue Shi, Xinyue Zhu, Yongjie Xu, Wei Cao, Fei Wang, Ni Li   +12 more
doaj   +1 more source

Use of claims data to identify adverse events after colonoscopy in a randomised colorectal cancer screening trial in Norway: a cross-sectional study

BMJ Open
Objectives Accurate identification of adverse events after colonoscopy is essential for quality assurance in colorectal cancer (CRC) screening. Review of medical records is labour intensive as adverse events are infrequent.
Michael Bretthauer, Edoardo Botteri, Øyvind Holme, Geir Hoff, Anna Lisa Schult, Øyvind Bakken Rognstad, Kristin Ranheim Randel, Hong Dung Nguyen   +7 more
doaj   +1 more source

Breast cancer in Iran: need for greater women awareness of warning signs and effective screening methods [PDF]

, 2008
Ali Montazeri, Mariam Vahdaninia, Iraj Harirchi, Amir Mahmood Harirchi, Akram Sajadian, Fatemeh Khaleghi, Mandana Ebrahimi, Shahpar Haghighat, Soghra Jarvandi   +8 more
openalex   +1 more source

Effects of nonparticipation at previous screening rounds on the characteristics of screen-detected breast cancers [PDF]

, 2022
Lucien E. M. Duijm, Mireille J. M. Broeders, Wikke Setz‐Pels, Vivian van Breest Smallenburg, Hermen C. van Beek, Astrid B. Donkers-van Rossum, Marjan J. Slob, Toon P. Kuipers, Ritse M. Mann, Adri C. Voogd   +9 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Total Body Skin Exam and Number Needed to Screen [PDF]

, 2019
Introduction/Background: Skin cancer screening could impact mortality and morbidity in US adults; however, the effectiveness of widespread screening remains unclear.
Bui, Michael, Hugo, Audra, Jones, MD, Elizabeth, Sherban, Alexander, Waseh, Shayan   +4 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source