Results 31 to 40 of about 816,942 (315)
Principles of Cancer Screening
Cancer Control, 1995 Early detection of cancer, prior to its clinical manifestations, appears to be a worthwhile and desirable goal. Yet, the concept and acceptance of cancer screening remain controversial and often confusing. While the benefits of screening are obvious to those whose screening tests have resulted in successful interventions, attention also needs to be ...
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
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Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
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BMC Gastroenterology, 2022 Background Guidelines on colorectal cancer (CRC) screening recommend screening of average-risk adults only. In addition, screening of individuals with active inflammatory bowel disease (IBD) might result in too many false-positive cases.
Pernille Thordal Larsen +2 more
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Self-reported symptoms among participants in a population-based screening program
Breast, 2020 Background: A limited number of studies have explored the association between self-reported symptoms and the risk of breast cancer among participants of population based screening programs.
Marthe Larsen +3 more
doaj
Testicular Cancer: To Screen or Not to Screen? [PDF]
Journal of Medical Screening, 1996 Objectives— To evaluate the evidence for and against routine testicular cancer screening by primary health care providers and patients (testicular self examination). Setting— Low reported frequency of routine screening for testicular cancer attributed to poor knowledge of the disease and how to screen for it. Methods— Literature based evaluation of the
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FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Familial Pancreatic Cancer: To Screen or not to Screen? [PDF]
EBioMedicine, 2015 In this issue of EBioMedicine, Pandharipande and colleagues report important data that may well assist the decision-making process when screening families at risk for pancreatic ductal adenocarcinoma (PDAC) (Pandharipande et al., 2015). The aim of the study was to compare, using a simulation model, the effectiveness of different screening strategies in
Vasen, H.F.A., Bartsch, D.
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FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
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