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Ultra-High-Frequency-Dielectrophoresis Microfluidic Biosensor to Detect the Transformation Potential of Extracellular Vesicles Derived from Cancer Stem Cells. [PDF]
Biosensors (Basel)Barthout E +12 more
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2016
The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
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The cancer stem cell model in solid tumors has evolved significantly from the early paradigm shifting work highlighting parallels between the stem cell hierarchy in hematologic malignancies and solid tumors. Putative stem cells can dedifferentiated, be induced by context, and be the result of accumulated genetic mutations.
Wendy A, Woodward, Richard P, Hill
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Journal of Clinical Oncology, 2008
Cellular heterogeneity in cancer was observed decades ago by studies in mice which showed that distinct subpopulations of cells within a tumor mass are capable of driving tumorigenesis. Conceptualized from this finding was the stem-cell hypothesis for cancer, which suggests that only a specific subset of cancer cells within each tumor is responsible ...
Cheong J, Lee +2 more
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Cellular heterogeneity in cancer was observed decades ago by studies in mice which showed that distinct subpopulations of cells within a tumor mass are capable of driving tumorigenesis. Conceptualized from this finding was the stem-cell hypothesis for cancer, which suggests that only a specific subset of cancer cells within each tumor is responsible ...
Cheong J, Lee +2 more
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Current Protocols in Stem Cell Biology, 2008
AbstractThis unit describes protocols for working with colon cancer stem cells. To work with these cells one must start by generating single‐cell suspensions from human colon cancer tissue. These cell suspensions are sorted using flow cytometry–assisted cell sorting to fractionate the cells into tumor‐initiating and nontumor‐initiating subsets.
Antonija, Kreso +1 more
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AbstractThis unit describes protocols for working with colon cancer stem cells. To work with these cells one must start by generating single‐cell suspensions from human colon cancer tissue. These cell suspensions are sorted using flow cytometry–assisted cell sorting to fractionate the cells into tumor‐initiating and nontumor‐initiating subsets.
Antonija, Kreso +1 more
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Gut, 2007
Colorectal cancer (CRC) is the third most common form of cancer and the second cause of cancer-related death in the Western world, leading to 655,000 deaths worldwide per year (Jemal et al. in CA Cancer J Clin 56:106–130, 2006). Despite the emergence of new targeted agents and the use of various therapeutic combinations, none of the treatment options ...
L, Ricci-Vitiani +4 more
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Colorectal cancer (CRC) is the third most common form of cancer and the second cause of cancer-related death in the Western world, leading to 655,000 deaths worldwide per year (Jemal et al. in CA Cancer J Clin 56:106–130, 2006). Despite the emergence of new targeted agents and the use of various therapeutic combinations, none of the treatment options ...
L, Ricci-Vitiani +4 more
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Expert Opinion on Therapeutic Targets, 2007
Recent evidence has demonstrated the existence of a small subset of the tumour mass that is wholly responsible for the sustained growth and propagation of the tumour. This cancer stem cell (CSC) compartment is also likely to be responsible both for disease relapse and the resistance to therapy that often accompanies relapse.
Brynn T, Kvinlaug, Brian J P, Huntly
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Recent evidence has demonstrated the existence of a small subset of the tumour mass that is wholly responsible for the sustained growth and propagation of the tumour. This cancer stem cell (CSC) compartment is also likely to be responsible both for disease relapse and the resistance to therapy that often accompanies relapse.
Brynn T, Kvinlaug, Brian J P, Huntly
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STEM CELLS, 2012
Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic aberrations. There are several issues concerning colorectal carcinogenesis that remain unanswered, such as the cell of origin and the type of cells that propagate the tumor after its ...
Aristides G, Vaiopoulos +3 more
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Colorectal cancer (CRC) is one of the most commonly diagnosed and lethal cancers worldwide. It is a multistep process that requires the accumulation of genetic/epigenetic aberrations. There are several issues concerning colorectal carcinogenesis that remain unanswered, such as the cell of origin and the type of cells that propagate the tumor after its ...
Aristides G, Vaiopoulos +3 more
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European Journal of Cancer, 2006
Prostate cancer is the most frequently diagnosed cancer in men. Despite recent advances in the detection of early prostate cancer there is little effective therapy for patients with locally advanced and/or metastatic disease. The majority of patients with advanced disease respond initially to androgen ablation therapy.
Anne T, Collins, Norman J, Maitland
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Prostate cancer is the most frequently diagnosed cancer in men. Despite recent advances in the detection of early prostate cancer there is little effective therapy for patients with locally advanced and/or metastatic disease. The majority of patients with advanced disease respond initially to androgen ablation therapy.
Anne T, Collins, Norman J, Maitland
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Current Stem Cell Research & Therapy, 2010
Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the "cancer stem cell (CSC ...
Mai N, Tran +3 more
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Stem cells are undifferentiated cells that renew themselves while simultaneously producing differentiated tissue- or organspecific cells through asymmetric cell division. The appreciation of the importance of stem cells in normal tissue biology has prompted the idea that cancers may also develop from a progenitor pool (the "cancer stem cell (CSC ...
Mai N, Tran +3 more
openaire +2 more sources