Results 121 to 130 of about 4,254,676 (261)

Cancer in Ireland 1994-2018 with estimates for 2018-2020: annual report of the National Cancer Registry 2020 [PDF]

, 2020
This year’s report estimates that numbers of invasive cancers (excluding non-melanoma skin cancer) have risen to about 24,753 cases diagnosed annually during 2018-2020 (13,152 males and 11,641 females), or 36,907 cases including all invasive cancers ...
National Cancer Registry Ireland (NCRI)
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Obesity and metabolic syndrome in adolescent survivors of standard risk childhood acute lymphoblastic leukemia in Saudi Arabia [PDF]

, 2012
This study estimated prevalence of unhealthy weight status and metabolic syndrome (MS) amongst Saudi survivors of standard risk ALL. Procedure. We recruited 56 survivors, mean age 13.4 years (SD 4.1), a mean of 9.1 years (SD 4.1) postdiagnosis.
Aldhafiri, Fahad, Al-Sugair, Abdulaziz, Al-Mutairi, Hanan, Reilly, John J, Al-Nasser, Abdallah, Young, David   +5 more
core   +1 more source

Trend and Cancer-Specific Prevalence of Kidney Stones Among US Cancer Survivors, 2007–2020

Current Oncology
Purpose: To evaluate the prevalence and cancer-specific patterns of kidney stones among U.S. cancer survivors compared to non-cancer adults. Methods: This was a serial cross-sectional, descriptive epidemiologic analysis of a US nationally representative ...
Chao Cao, Ruixuan Wang, Xiangren Wang, Mohammad Abufaraj, Thomas Waldhoer, Geoffrey T. Gotto, Shahrokh F. Shariat, Lin Yang   +7 more
doaj   +1 more source

Physical activity among breast cancer survivors [PDF]

, 2008
In Australia, women with breast cancer comprise one of the largest groups of cancer survivors. As a consequence of this, and improved survival rates, the interest in programs to enhance the recovery of cancer survivors is growing.
Harrison, Sheree
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Physical Activity Programs for Adult Cancer Survivors in Atlantic Canada

, 2018
Although physical activity (PA) has been found to be a safe and effective way to mitigate many of the side-effects of cancer and cancer treatment, PA levels among cancer survivors remain low.
Shea, Kelsey M.
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source