Results 131 to 140 of about 1,141,790 (161)
iScienceSummary: Transforming growth factor β (TGF-β) is abundantly present in the tumor microenvironment, contributing to cancer progression. However, the regulatory mechanism by which TGF-β affects vascular endothelial cells (ECs) in the tumor microenvironment
Kako Hanada +9 more
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A global protein–lipid interactome map
Molecular Systems Biology, 2010 Marc Brehme, Marc Vidal
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Methods in molecular biology, 2016
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
D. Faratian +4 more
semanticscholar +4 more sources
Cancer is a complex and heterogeneous disease, not only at a genetic and biochemical level, but also at a tissue, organism, and population level. Multiple data streams, from reductionist biochemistry in vitro to high-throughput "-omics" from clinical material, have been generated with the hope that they encode useful information about phenotype and ...
D. Faratian +4 more
semanticscholar +4 more sources
Systems Biology Approaches in Cancer Pathology. [PDF]
Methods in molecular biology, 2018 The complex network of the tissue system, in both pre-neoplastic tissues and tumors, demonstrates the need for a systems biology approach to cancer pathology, in which quantification of key tissue system processes is combined with informatics tools to produce actionable scores to aid clinical decision-making.
Aaron D. Deward, R. Critchley-Thorne
semanticscholar +3 more sources
Handbook of Statistical Bioinformatics, 2011
Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
E. Fertig, Ludmila V. Danilova, M. Ochs
semanticscholar +3 more sources
Cancer is a complex disease, resulting from system-wide interactions of biological processes rather than from any single underlying cause. The processes that drive all cancer development and progression have been termed the ‘hallmarks of cancer’. With the growth of large-scale measurements of numerous molecular and cellular properties, a new approach ...
E. Fertig, Ludmila V. Danilova, M. Ochs
semanticscholar +3 more sources
Current Opinion in Oncology, 2005
Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G Khalil, C Hill
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Significant insight can be gained into complex biologic mechanisms of cancer via a combined computational and experimental systems biology approach. This review highlights some of the major systems biology efforts that were applied to cancer in the past year.Two main approaches to computational systems biology are discussed: mechanistic dynamical ...
I G Khalil, C Hill
openaire +3 more sources
Cancer: A Systems Biology disease
Biosystems, 2006Cancer research has focused on the identification of molecular differences between cancerous and healthy cells. The emerging picture is overwhelmingly complex. Molecules out of many parallel signal transduction pathways are involved. Their activities appear to be controlled by multiple factors.
Hans V. Westerhoff +5 more
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Computational Systems Biology of Cancer
, 2020Introduction: Why Systems Biology of Cancer? Cancer is a major health issue From genome to genes to network Cancer research as a big science Cancer is a heterogeneous disease Cancer requires personalised medicine What is systems biology?
E. Barillot +4 more
semanticscholar +1 more source
Realizing Cancer Precision Medicine by Integrating Systems Biology and Nanomaterial Engineering
Advances in Materials, 2020Many clinical trials for cancer precision medicine have yielded unsatisfactory results due to challenges such as drug resistance and low efficacy. Drug resistance is often caused by the complex compensatory regulation within the biomolecular network in a
J. Joo +6 more
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