Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status [PDF]
, 2008 Bin Yan +7 more
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Molecular Oncology, EarlyView.The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang +3 more
wiley +1 more source
A census of pathway maps in cancer systems biology. [PDF]
Nat Rev Cancer, 2020 Kuenzi BM, Ideker T.
europepmc +1 more source
Predictive modeling in cancer: where systems biology meets the stock market [PDF]
, 2009 Maysam Abbod +3 more
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The Cancer Diaspora: Metastasis beyond the seed and soil hypothesis [PDF]
arXiv, 2013 Do cancer cells escape their confinement of their original habitat in the primary tumor or are they forced out by ecological changes in their home niche? Describing metastasis in terms of a simple one-way migration of cells from the primary to target organs is an insufficient concept to cover the nuances of cancer spread.
arxiv
Molecular Oncology, EarlyView.Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou +11 more
wiley +1 more source
Beyond HER2 and Trastuzumab: Heterogeneity, Systems Biology, and Cancer Origin Research May Guide the Future for Personalized Treatment of Very Early but Aggressive Breast Cancer [PDF]
, 2010 Dimitrios H Roukos
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Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
iScience, 2021 Summary: Recent findings indicate that changes underlying cancer onset and progression are not only attributable to changes in DNA structure and expression of individual genes but to changes in interactions among these genes as well.
Zainab Arshad, John F. McDonald
doaj
A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer [PDF]
, 2011 Wendy L. Allen +10 more
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