Results 241 to 250 of about 2,969,292 (313)

Ultrasound-Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications. [PDF]

Adv Sci (Weinh)
Wang X, Xu W, Lu Y, Yu H, Zha Z, Zhang X.   +5 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Natural bioactive molecules and chemotherapeutics synergism for enhanced cancer therapy. [PDF]

Nutr Metab (Lond)
Hashemi M, Heshmatzad K, Shahsavan G, Tavakolpour V, Komeilie Esfahani S, Karimi P, Beikzadeh N, Mashhadikhan S, Nasirzade S, Vasheghani Farahani A, Zali N, Cho WC, Taheriazam A, Maghrebi-Ghojogh E, Alimohammadi M, Rahimzadeh P, Hushmandi K, Entezari M.   +17 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Polymersome-based nanomedicine for combined cancer therapy. [PDF]

Drug Deliv
Mohammadi Zonouz A, Ebrahimpour M, Zibaei K, Ramezani M, Taghavi S, Abnous K, Taghdisi SM, Alibolandi M.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Natural Modulators of Aquaporins in Cancer Therapy: Functional Mechanisms and Clinical Potential. [PDF]

Molecules
Małkowska P, Tarnowski M.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The roles and pathways of Hsa_circ_0000285 in cancer: a potential target for cancer therapy. [PDF]

Cell Div
Lv Y, Li D, Zhang QX, Zeng T, Luo XY, Guo Q, Ren QY.   +6 more
europepmc   +1 more source