Results 101 to 110 of about 174,873,894 (246)

CIP2A expression is upregulated in triple-negative breast cancer [PDF]

, 2015
Introduction: Expression of cancerous inhibitor of protein phosphatase 2A (CIP2A) has been correlated with the clinical aggression and progression of breast cancer. CIP2A inhibits protein phosphatase 2A promoting proliferation and survival.
Baldacchino, Shawn, Speirs, Valerie, Hughes, Thomas A., Wastall, Laura, Ninth Malta Medical School Conference, Saliba, Christian, Grech, Godfrey   +6 more
core  

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source

is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase‐1

, 1986
The dephosphorylation of glycogen synthase by protein phosphatase-1 in hepatic glycogen and microsomes was inhibited by nanomolar concentrations of phosphorylase a. The I50 for phosphorylase a was 1000-fold lower than its Km as a substrate, while tryptic
Susana Alemany, Philip Cohen, Cohen, Philip; id_orcid, Alemany, Susana   +3 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

PPP1R8 (protein phosphatase 1, regulatory (inhibitor) subunit 8) [PDF]

, 2011
Review on PPP1R8 (protein phosphatase 1, regulatory (inhibitor) subunit 8), with data on DNA, on the protein encoded, and where the gene is ...
Van, Dessel N, Beullens, M, van, Eynde A, Bollen, M, Minnebo, N   +4 more
core   +1 more source

Biomimetic PD-1 macrophage nanoplatform for Cip2a silencing and immune activation in oral squamous cell carcinoma

Journal of Nanobiotechnology
Oral squamous cell carcinoma (OSCC) remains a highly aggressive malignancy in which immune checkpoint blockade alone shows limited efficacy due to persistent tumor-intrinsic survival signaling and an immunosuppressive tumor microenvironment.
Chenyu Zhang, Zhe Yuan, Jie Zhou, Huizhu Yan, Zhong Liu, Xinyue Zhang, Yuxia Zhang, Shuo Zhang, Lijuan Zhu, Dali Wang, Bing Liu   +10 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Spirastrellolide A:  Revised Structure, Progress toward the Relative Configuration, and Inhibition of Protein Phosphatase 2A

, 2016
The structure of spirastrellolide A, a novel macrolide isolated from the marine sponge Spirastrella coccinea, has been revised to accommodate new MS and chemical transformation data.
Tamsin Tarling (2071516), Raymond J. Andersen (155984), Marshall Lapawa (2712136), Xidong Feng (2104480), Michel Roberge (155980), David E. Williams (155960)   +5 more
core   +1 more source

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source