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Cancerous Inhibitor of Protein Phosphatase 2A Regulates P21 and COL1A1 Expression in Lung Fibroblasts

American Journal of Respiratory and Critical Care Medicine
D. Nirmal   +13 more
semanticscholar   +2 more sources

Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein.

Gynecologic Oncology, 2011
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein stabilizing c-Myc and promoting cell proliferation and transformation. Here we investigated the role of CIP2A in cervical cancer in vivo and in vitro.CIP2A expression was assessed in normal cervical, cervical intraepithelial neoplasia (CIN) I to III and cervical ...
Juan Liu   +9 more
semanticscholar   +3 more sources

The association and prognostic relevance of cancerous inhibitor of protein phosphatase 2A and inflammation in tongue squamous cell carcinoma

APMIS, 2015
Cancerous inhibitor of protein phosphatase 2A (CIP2A) prevents proteolytic degradation of a universal transcription factor, c‐Myc. Strong CIP2A expression associates with poor prognosis in early‐stage tongue cancer and in other cancers. The aim of this study was to evaluate CIP2A and mucosal inflammation in tongue hyperplasia, in tongue cancer, and in ...
M. Seppälä   +6 more
semanticscholar   +3 more sources

Abstract A34: Targeting Protein Phosphatase 2A in Combination with PARP inhibitors for the treatment of high-grade serous epithelial ovarian cancer

Clinical Cancer Research, 2020
Abstract Ovarian cancer (OvC) is the deadliest of all female gynecologic malignancies, ranking as the fifth cause of cancer-related deaths among women. High-grade serous epithelial ovarian cancer (HGSOC) accounts for almost 90% of all forms of OvC, remaining as the most lethal subtype of ovarian malignancies.
Rita A. Avelar   +3 more
openaire   +1 more source

Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

European Journal of Cancer, 2011
Protein phosphatase 2A (PP2A) is a multimeric serine/threonine phosphatase that can dephosphorylate multiple kinases. It is generally considered to be a cancer suppressor as its inhibition can induce phosphorylation and activation of substrate kinases that mainly accelerate growth.
Wei, Li   +11 more
openaire   +2 more sources

[Expression of cancerous inhibitor of protein phosphatase 2A in tissue microarray of colorectal cancer and its clinical significance].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2015
To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer, and to examine the association of CIP2A expression with clinicopathology and prognosis.CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.Up-regulated CIP2A expression was closely
Xing-yu, Peng   +5 more
openaire   +1 more source

The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

Ca-A Cancer Journal for Clinicians, 2022
Sharon Elad, Noam Yarom, Yehuda Zadik
exaly  

The contemporary management of cancers of the sinonasal tract in adults

Ca-A Cancer Journal for Clinicians, 2023
Rajat Thawani
exaly  

Treatment of renal cell carcinoma: Current status and future directions

Ca-A Cancer Journal for Clinicians, 2017
Pedro Coelho Barata, Brian I Rini
exaly  

Highly accurate protein structure prediction with AlphaFold

Nature, 2021
John M Jumper   +2 more
exaly  

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