Results 101 to 110 of about 108,048 (261)

Study of Changing Trend in the Clinical Distribution of Candida Species in Various Clinical Samples at Tertiary Care Hospital, Ahmedabad, Gujarat

National Journal of Community Medicine, 2017
Introduction: The incidence of fungal infections has increased significantly, contributing to morbidity and mortality. Candida albicans remains the most common species causing human infections but recent epidemiological data reveal shift from C ...
Hetal Sida, Jayshri Pethani, Parevee Dalal, Hiral Shah   +3 more
doaj  

16S/18S metabarcoding versus culture for aetiological assessment in infectious keratitis: A prospective paired‐sample study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Infectious keratitis (IK) is a vision‐threatening condition with diverse microbial aetiologies, yet conventional culture‐based diagnostics often have limited sensitivity. We investigated whether 16S/18S rRNA amplicon‐based next‐generation sequencing (NGS) can enhance aetiological assessment when used alongside standard microbiological ...
Sandra M. Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Lise Kristensen, Anders Ivarsen   +6 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Incidence of Culture‐Proven Neonatal Sepsis and Its Correlation With Nurse Staffing in a Level IV Neonatal Intensive Care Unit: A Six‐Year Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim To assess the incidence of culture‐proven sepsis and examine the correlation between positive blood cultures and nurse staffing in a Level IV neonatal intensive care unit (NICU). Methods This retrospective cohort study included neonates with ≥ 1 positive blood culture and signs of infection between 2018 and 2023.
A. Gudiksen, M. Breindahl, F. B. Hertz, J. D. Knudsen, S. A. Beck, S. G. Herrmann, L. Aunsholt, E. M. Carlsen   +7 more
wiley   +1 more source

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide study of patients with inflammatory bowel disease, TNF inhibitor use was associated with higher bloodstream infection rates, whereas vedolizumab and ustekinumab was not. Associations differed by pathogen species, and concomitant glucocorticoid use was associated with higher infection rates.
Cæcilie Leding, Alessandra Meddis, Jon Gitz Holler, Johan Burisch, Thomas Benfield   +4 more
wiley   +1 more source

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

Testing for Bacteria and Fungi in Cells and Ancillary Reagents—Probe‐Based Quantitative PCR Assays

Cell Proliferation, EarlyView.
This document specifies the technical elements for bacteria and fungi detection by PCR assay which enables rapid, broad‐spectrum detection of bacteria and fungi with high sensitivity. Qualitative judgement is based on LOD. Key detection points include efficient nucleic acid extraction, broad‐spectrum primer‐probe design, high amplification efficiency ...
Jiani Cao, Ranran Xu, Boqiang Fu, Jie Hao, Lei Wang, Aijin Ma, Qiang Wei, Hongling Zhao, Chunming Rao, Qiyuan Li, Tao Na, Shijun Hu, Lihua Zhou, Weiqi Zhang, Qubo Chen, Siming Sun, Zengshu Liu, Shuaishuai Niu, Tingting Zhang, Yuanyuan Zhang, Yidi Gan, Shuyan Wang, Glyn N. Stacey, Jun Wei, Tongbiao Zhao, Yu Alex Zhang   +25 more
wiley   +1 more source

The Determination of Vaginal Candidiasis inWomen Referred to Shahid Rajaei Hospital in Tonekabon(2009-2010)

Medical Laboratory Journal, 2011
Background and objectives: Genital tract infections are among the most common causes of patients referred to therapeutic centers. Nearly 75% of women suffer from genital Candida infection, at least once in their lifetime.
Nasrollahi omran A(PhD), Vakili L(MSc), Jafarpur M(PhD)   +2 more
doaj  

Transmembrane MUC1 assists oral microbial colonization in oral mucosa of potentially malignant disorders and oral squamous carcinoma

European Journal of Oral Sciences, EarlyView.
Abstract Transmembrane mucin 1 (tMUC1) provides oral mucosal barrier against pathogens. The invasion of oncopathogenic microbes can promote cancerous proliferation of cells via inflammatory responses, abnormal cellular signaling, angiogenesis, anti‐adhesion, and tumorigenesis.
Lauriina Soiniemi, Matias Kanniainen, Saga Ramsay, Arja Kullaa, Bina Kashyap   +4 more
wiley   +1 more source

Mitochondrial iron homeostasis is required for azole tolerance in Candida albicans

The FEBS Journal, EarlyView.
In Candida albicans, the deletion of MRS4, which encodes a mitochondrial iron importer, abolishes fluconazole tolerance and increases cidality during cotreatment with the iron chelator BPS, without altering MIC or synergy. Fluconazole‐treated mutants exhibit increased mitochondrial depolarisation, fragmentation and reduced mitochondrial density.
Wouter Van Genechten, Gauthier Cornips, Martine De Jonge, Rudy Vergauwen, Patrick Van Dijck   +4 more
wiley   +1 more source