Results 221 to 230 of about 1,567,650 (332)

From known chemical space to unannotated metabolites: a cluster-guided retention-time driven framework for biologically informed annotation. [PDF]

Metabolomics
Bhandari D, Paz HA, Henderson K, Adepu KK, Mani-Varnosfaderani A, Assress HA, Piccolo BD, Lan RS, Børsheim E, Kay CD, Chintapalli SV.   +10 more
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Hepatitis A vaccination during ventricular assist device support in heart transplant candidates: immunogenicity and safety in a single-center cohort. [PDF]

J Artif Organs
Arima M, Yamamoto S, Adachi-Katayama M, Okamoto K, Ando M, Okugawa S, Ono M, Tsutsumi T.   +7 more
europepmc   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

A Problem-Setup-Centric Framework for Mixed-Variable Chemical Formulation Optimization with Customized Constraints. [PDF]

Materials (Basel)
Zhang Y, Chen S, Gao S, Xu P, Lu W.
europepmc   +1 more source

Integrative Transcriptomic and Network Pharmacology Analysis Reveals Candidate Molecular Associations and Hypothesis-Generating Drug-Gene Relationships in Major Depressive Disorder

Laura Gomes Libório, Sophia Massesine Pimentel, Sara Laíse Cordeiro   +2 more
openalex   +1 more source

Paramagnetic Rim Lesions and Choroid Plexus Volume at Diagnosis Are Associated With Cognitive Progression Independent of Relapse and MRI Activity in Early Relapsing–Remitting Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) and choroid plexus (CP) enlargement reflect smoldering inflammation in multiple sclerosis. Their role in cognitive progression remains unexplored. Eighty‐seven early relapsing–remitting MS patients were enrolled at diagnosis and followed longitudinally.
Stefano Ziccardi, Damiano Marastoni, Agnese Tamanti, Pietro Biasi, Valentina Visani, Annalisa Colombi, Tom A. Fuchs, Monica Sicchieri, Chiara Eccher, Francesco Guarnaccia, Milena Calderone, Valentina Camera, Francesca Benedetta Pizzini, Roberta Magliozzi, Marco Castellaro, Massimiliano Calabrese   +15 more
wiley   +1 more source

Quantifying Influence: The Orthopaedic PAC's Impact Explored Through Analysis of FEC Data. [PDF]

J Am Acad Orthop Surg Glob Res Rev
Nadarajah V, Barnes M, Belding J, Nwankwo BO, Stephens SE, Chhabra AB, Deasey MJ.   +6 more
europepmc   +1 more source