Results 51 to 60 of about 4,868 (133)

Interleukin 17-Mediated Host Defense against Candida albicans

Pathogens, 2015
Candida albicans is part of the normal microbiota in most healthy individuals. However, it can cause opportunistic infections if host defenses are breached, with symptoms ranging from superficial lesions to severe systemic disease.
Florian Sparber, Salomé LeibundGut-Landmann   +1 more
doaj   +1 more source

Efficacy and Safety of Oral Icotrokinra in Moderate‐to‐Severe Plaque Psoriasis: A Systematic Review, Meta‐Analysis, and Trial Sequential Analysis

International Journal of Dermatology, Volume 65, Issue 6, Page 1144-1154, June 2026.
Meta‐analysis of randomized controlled trials demonstrates that oral icotrokinra significantly improves PASI responses in patients with moderate‐to‐severe plaque psoriasis, with early clinical benefit and a placebo‐comparable safety profile, supported by trial sequential analysis confirming robust and sufficient evidence.
Alhasan Altayf, Munder Lateiresh, Lutfiyah Marwan, Mohamed Yaseen Alfeetouri, Yassine Zouaoui, Muhammed Elhadi   +5 more
wiley   +1 more source

Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea

JPGN Reports, Volume 7, Issue 2, Page 242-246, May 2026.
Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno, Angelo Corso Faini, Silvia Deaglio, Marianna Pellegrini, Raffaele Buganza, Francesca Giuliani, Pier Luigi Calvo, Michele Pinon   +7 more
wiley   +1 more source

Immune Dysregulation and Chronic Mucocutaneous Candidiasis in a Child With STAT1 Gain-of-function Mutation: A Case Report and Literature Review [PDF]

Journal of Pediatrics Review
Background: Chronic mucocutaneous candidiasis (CMC) is most commonly associated with gain-of-function (GOF) mutations in STAT1, which impair immune regulation and predispose to recurrent fungal infections, autoimmunity, and lymphoproliferative disorders.
Fateme Davari, Saber Mehdizadeh, Mirhamed Hoseini-Aghdam, Abbas Dabbaghzadeh   +3 more
doaj  

The Role of IL-17 in Protection against Mucosal Candida Infections

Journal of Fungi, 2017
Interleukin-17 (IL-17) is a proinflammatory cytokine produced by adaptive CD4+ T helper cells and innate lymphocytes, such as γδ-T cells and TCRβ+ “natural” Th17 cells.
Bemnet G. Mengesha, Heather R. Conti
doaj   +1 more source

Gain-of-Function Mutations in STAT1: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies

Case Reports in Immunology, 2017
Chronic Mucocutaneous Candidiasis (CMC) is the chronic, recurrent, noninvasive Candida infections of the skin, mucous membranes, and nails. A 26-month-old girl was admitted with the complaints of recurrent oral Candidiasis, diarrhea, and respiratory ...
Sanem Eren Akarcan, Ezgi Ulusoy Severcan, Neslihan Edeer Karaca, Esra Isik, Guzide Aksu, Mélanie Migaud, Ferda Evin Gurkan, Elif Azarsiz, Anne Puel, Jean-Laurent Casanova, Necil Kutukculer   +10 more
doaj   +1 more source

Chronic Mucocutaneous Candidiasis; Report of Three Cases with Different Phenotypes

Iranian Journal of Allergy, Asthma and Immunology, 2005
Despite the fact that higher BMI is a risk factor for, wheeze ever, wheeze and dyspnea in the last 12 months, and diagnosed asthma, higher BMI is not a risk factor for obstructive pattern in pulmonary function test.
Mohammad Reza Fazlollahi, Abolhassan Farhoudi, Masoud Movahedi, Mohammad Gharagozlou, Kourosh Mohammadi, Nima Rezaei   +5 more
doaj  

Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

Mediators of Inflammation, 2003
Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular ...
S. Gangemi, A. Saija, A. Tomaino, F. Cimino, R. A. Merendino, P. L. Minciullo, S. Briuglia, M. V. Merlino, B. Dallapiccola, B. Ferlazzo, D. C. Salpietro   +10 more
doaj   +1 more source

Early-onset Chronic Keratitis as the First Presenting Component of Autoimmune Polyendocrine Syndrome Type 1: A Case Report and Review of the Literature

JCRPE
Autoimmune polyendocrine syndrome type 1 (APS-1), also referred to as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, is a rare monogenic autosomal recessive autoimmune disease. It is caused by mutations in the autoimmune regulator (AIRE)
Enver Şimşek, Tülay Şimşek, Oğuz Çilingir   +2 more
doaj   +1 more source

Oral Administration of Human Polyvalent IgG by Mouthwash as an Adjunctive Treatment of Chronic Oral Candidiasis

Frontiers in Immunology, 2018
Candida albicans is a commensal fungus that can cause disease ranging in severity from moderate to severe mucosal infections to more serious life-threating disseminated infections in severely immunocompromised hosts.
Sigifredo Pedraza-Sánchez, Julia I. Méndez-León, Yolanda Gonzalez, María Laura Ventura-Ayala, María Teresa Herrera, Jose Luis Lezana-Fernández, Joseph A. Bellanti, Martha Torres   +7 more
doaj   +1 more source