Results 41 to 50 of about 1,234 (112)

Focal lesions following intracerebral gene therapy for mucopolysaccharidosis IIIA

Annals of Clinical and Translational Neurology, Volume 10, Issue 6, Page 904-917, June 2023., 2023
Abstract Objective Mucopolysaccharidosis type IIIA (MPSIIIA) caused by recessive SGSH variants results in sulfamidase deficiency, leading to neurocognitive decline and death. No disease‐modifying therapy is available. The AAVance gene therapy trial investigates AAVrh.10 overexpressing human sulfamidase (LYS‐SAF302) delivered by intracerebral injection ...
Marianna Bugiani, Truus E. M. Abbink, Arthur W. D. Edridge, Lia van der Hoek, Anne E. J. Hillen, Niek P. van Til, Gino V. Hu‐A‐Ng, Marjolein Breur, Karen Aiach, Philippe Drevot, Michaël Hocquemiller, Ralph Laufer, Frits A. Wijburg, Marjo S. van der Knaap   +13 more
wiley   +1 more source

Integrated Use of Molecular Techniques to Detect and Genetically Characterise DNA Viruses in Italian Wolves (Canis lupus italicus)

Animals, 2021
In this study, internal organs (tongue, intestine, and spleen) of 23 free-ranging Italian wolves (Canis lupus italicus) found dead between 2017 and 2019 were tested for Carnivore protoparvovirus 1, Canine adenovirus (CAdV), and Canine circovirus ...
Andrea Balboni, Lorenza Urbani, Mauro Delogu, Carmela Musto, Maria Cristina Fontana, Giuseppe Merialdi, Giuseppe Lucifora, Alessia Terrusi, Francesco Dondi, Mara Battilani   +9 more
doaj   +1 more source

Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus

Advanced Science, Volume 10, Issue 17, June 13, 2023., 2023
mFeS induces the viral ferroptosis by enhancing the lipid peroxidation level, which results in a failed viral infection. In addition, Dc(mFeS) suppresses the cellular ferroptosis‐dependent intracellular replication of influenza virus via restoring influenza virus‐induced imbalance of sulfur metabolism, and the supply of intracellular S0 ...
Xinyu Miao, Yinyan Yin, Yulian Chen, Wenhui Bi, Yuncong Yin, Sujuan Chen, Daxin Peng, Lizeng Gao, Tao Qin, Xiufan Liu   +9 more
wiley   +1 more source

Detection and Genetic Characterization of Canine Adenoviruses, Circoviruses, and Novel Cycloviruses From Wild Carnivores in Italy

Frontiers in Veterinary Science, 2022
Wild carnivores are known to play a role in the epidemiology of several canine viruses, including canine adenoviruses types 1 (CAdV-1) and 2 (CAdV-2), canine circovirus (CanineCV) and canine distemper virus (CDV).
Linda A. Ndiana, Gianvito Lanave, Violetta Vasinioti, Costantina Desario, Camillo Martino, Maria Loredana Colaianni, Francesco Pellegrini, Antonio Camarda, Shadia Berjaoui, Giovanni Sgroi, Gabriella Elia, Annamaria Pratelli, Francesco Buono, Vito Martella, Canio Buonavoglia, Nicola Decaro   +15 more
doaj   +1 more source

Fatal canine parvovirus type 2a and 2c infections in wild Chinese pangolins (Manis pentadactyla) in southern China

Transboundary and Emerging Diseases, Volume 69, Issue 6, Page 4002-4008, November 2022., 2022
Abstract The Chinese pangolin (Manis pentadactyla) is a critically endangered scale‐covered mammal belonging to the order Pholidota. Wild pangolins are notably susceptible to pathogen infection and are typically characterized by impoverished health. However, little is currently known regarding the viruses prevalent among pangolins.
Zhang Lina, Wang Kai, An Fuyu, Zhang Dongliang, Zhang Hailing, Xu Xuelin, Guo Ce, Yan Hongmei, Kuang Yingjie, Zhang Zhidong, Lu Rongguang, Hua Yan   +11 more
wiley   +1 more source

Molecular epidemiology of Canine circovirus in domestic dogs and wildlife in Namibia, Africa

Infection, Genetics and Evolution, 2023
Canine circovirus (CanineCV) is a DNA virus affecting domestic dogs and other wild carnivore species. Despite the potential implications for dogs' health and wildlife conservation, data on CanineCV presence, epidemiology and genetic features from Africa is still poor.
de Villiers L., Molini U., Coetzee L. M., Visser L., Spangenberg J., de Villiers M., Berjaoui S., Khaiseb S., Lorusso A., Franzo G.   +9 more
openaire   +2 more sources

Circovirus in Tissues of Dogs with Vasculitis and Hemorrhage

Emerging Infectious Diseases, 2013
We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis.
Linlin Li, Sabrina McGraw, Kevin Zhu, Christian M. Leutenegger, Stanley L. Marks, Steven Kubiski, Patricia Gaffney, Florante N. Dela Cruz Jr, Chunlin Wang, Eric Delwart, Patricia A. Pesavento   +10 more
doaj   +1 more source

Multiplex PCR methods for detection of several viruses associated with canine respiratory and enteric diseases.

PLoS ONE, 2019
Viral respiratory and intestinal infections are the most common causes of canine viral illness. Infection with multiple pathogens occurs in many cases. Rapid diagnosis of these multiple infections is important for providing timely and effective treatment.
Xiangqi Hao, Ruohan Liu, Yuwei He, Xiangyu Xiao, Weiqi Xiao, Qingxu Zheng, Xi Lin, Pan Tao, Pei Zhou, Shoujun Li   +9 more
doaj   +1 more source

Novel Cyclovirus Species in Dogs with Hemorrhagic Gastroenteritis

Viruses, 2021
Nested PCRs with circovirus/cyclovirus pan-rep (replicase gene) primers detected eukaryotic circular Rep-encoding single-stranded DNA (CRESS DNA) viruses in three (samples CN9E, CN16E and CN34) of 18 canine parvovirus-2-positive fecal samples from ...
Kerry Gainor, Yashpal S. Malik, Souvik Ghosh   +2 more
doaj   +1 more source

Divergent Effects of Circoviridae Capsid Proteins on Type I Interferon Signaling

Pathogens
Viruses in the Circoviridae family can infect mammals and birds. Porcine circovirus type 2 (PCV2) significantly affects the livestock industry by causing porcine circovirus-associated diseases, such as postweaning multisystem wasting syndrome ...
Anon H. Kosaka, Chen-Yu Huang, Zih-Ying Lu, Hua-Zhen Hsing, Amonrat Choonnasard, Rissar Siringo Ringo, Kuo Pin Chuang, Akatsuki Saito   +7 more
doaj   +1 more source