Results 171 to 180 of about 31,819 (298)

Interictal burden in migraine: a systematic review of conceptual domains and measurement properties of instruments. [PDF]

J Headache Pain
Angerhöfer C, Fuse Y, Van Langenhove S, Canning T, von Alvensleben AC, Ahmad S, Murillo A, Boada L, Roque MM, MaassenVanDenBrink A, Lampl C, European Headache Federation School of Advanced Studies (EHF-SAS).   +11 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Iso-pseudoprolines as versatile tools for late-stage peptide backbone modifications. [PDF]

Chem Sci
Milewska KD, Schwartz BD, Canning JR, Modak U, Attard FC, Gardiner MG, Van Raad D, Huber T, Malins LR.   +8 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Nanosensitive optical coherence tomography to monitor corneal burn and treatment response in vivo. [PDF]

Biomed Opt Express
Johnston E, Alexandrov S, Dey R, Donohoe E, Canning A, Ritter T, Leahy M.   +6 more
europepmc   +1 more source

Can-can Carlista

[183-?]
openaire   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Histories of sardine fisheries. architecture and environment in the Bay of Biscay (1846-1965). [PDF]

Open Res Eur
Nouvet A, Tavares A, Secci-Petretto G, Sousa Santos R, Eyjólfsson G, Gabriel S, Soares C, Inglez de Souza D, Sillero N.   +8 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The effect of virtual reality on exercise execution in people with Parkinson's disease. [PDF]

Front Psychol
Seuthe J, Grotherr J, Kauter A, Barbieri FA, Hauptmann B, Schlenstedt C.   +5 more
europepmc   +1 more source