Results 91 to 100 of about 13,392 (217)

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Cumulative incidence and treatment of non-simultaneous bilateral femoral neck fractures in a cohort of one thousand two hundred and fifty patients [PDF]

, 2014
Purpose In the Netherlands, over 20,000 patients sustain a hip fracture yearly. A first hip fracture is a risk factor for a second,
Burgers, P.T.P.W. (Paul), Heetveld, M.J. (Martin), Lieshout, E.M.M. (Esther) van, Mailuhu, A.K.E. (Adinda), Patka, P. (Peter), Poolman, R.W. (Rudolf), Roukema, G.R. (Gert), Verhofstad, M.H.J. (Michiel), Zielinski, S.M. (Stephanie)   +8 more
core   +1 more source

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Jing Zhou, Benjamin H. Wang, Jiangning Yu, Guoxiang Wang, Jingyi Cai, Mohan Yu, Kehua Chen, Li Wan, Xu Liu, Zhigang Yang, Yulong Wang, Yun Wang   +11 more
wiley   +1 more source

Radiographic and histologic effects of bone morphogenetic protein-2/hydroxyapatite within bioabsorbable magnesium screws in a rabbit model

Journal of Orthopaedic Surgery and Research, 2019
Background Hydrogen gas formed by magnesium (Mg) screw corrosion can accumulate around the implant and create bone cysts, long-term osteolysis lesions, and bone healing delay. Thus, several authors currently do not recommend Mg implants for clinical use.
Le Hoang Nam Dang, Yu Kyoung Kim, Seo Young Kim, Kuk Jin Lim, Ken Bode, Min Ho Lee, Kwang Bok Lee   +6 more
doaj   +1 more source

Intramedullary screw fixation in proximal fifth-metatarsal fractures in sports: clinical and biomechanical analysis [PDF]

, 2018
Introduction and purpose: Intramedullary screw fixation (ISF) of proximal fifth-metatarsal fractures is known as first treatment option in young, sports active patients. No study analyzed functional and biomechanical outcome before.
Fuhr, Peter, Hintermann, Beat, Leumann, André, Pagenstert, Geert, Valderrabano, Victor   +4 more
core  

Biomechanical Study Using the Finite Element Method of Internal Fixation in Pauwels Type III Vertical Femoral Neck Fractures [PDF]

, 2015
Background: Several factors are known to influence osseous union of femoral neck fractures. Numerous clinical studies have reported different results, hence with different recommendations regarding treatment of Pauwels III fractures: femoral neck ...
Adachi, K., Naoi, K., Noda, M., Saegusa, Y., Takahashi, M., Tezuka, D.   +5 more
core   +1 more source

Comparison of the Dynamic Cut‐Out Failure Modes of Common Proximal Femoral Fixation Devices Using a Mesh‐Free Computational Method

Journal of Orthopaedic Research, Volume 44, Issue 2, February 2026.
Migration and cut‐out of DHS, Gamma3, PFNA‐II, and TFNA were compared under dynamic loading in a stable intertrochanteric fracture benchtop foam model and a mesh‐free simulation. No significant differences in force at cut‐out were observed, but simulation revealed that the volumes of damaged bone foam were 15%, 32%, and 25% higher for the Gamma3, PFNA,
Erica Ueda Boles, Sloan Kulper, Katie Whiffin, Marilyn Janice Oentaryo, Kerstin Schneider, Frankie Leung, Christian X. Fang   +6 more
wiley   +1 more source

A Mixed‐Reality Navigation Simulator for Training Infiltration Procedures of the Spine: Evaluation in Kambin Triangle Location

The International Journal of Medical Robotics and Computer Assisted Surgery, Volume 22, Issue 1, February 2026.
ABSTRACT Background During minimally invasive surgeries, the Kambin Triangle infiltration procedure is primarily used as a safe anatomical access route to critical spine structures. Inadequate location of final infiltrations can be critical for inexperienced residents.
César F. Domínguez‐Velasco, Jessica Alatorre‐Flores, Jorge A. Pérez‐Terrazas, Efrain Albor‐Ramírez, Felipe Camarillo‐Juárez, Marino A. Capurso‐García, Fabrizio Cutolo, Vincenzo Ferrari, Miguel A. Padilla‐Castañeda   +8 more
wiley   +1 more source

Role of screw proximity in the fixation of transverse patellar fractures with screws and a wire

Journal of Orthopaedic Surgery, 2018
Purpose: Clinical and biomechanical studies have reported that using supportive screws and a wire instead of the common Kirschner wires for modified tension band wiring improves the stability of fractured patellae.
Chih-Wei Chang, Yen-Nien Chen, Chun-Ting Li, Yu-Hsuan Chung, Chih-Han Chang, Yao-Te Peng   +5 more
doaj   +1 more source