Results 111 to 120 of about 245,619 (256)

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

Cumulative incidence and treatment of non-simultaneous bilateral femoral neck fractures in a cohort of one thousand two hundred and fifty patients [PDF]

, 2014
Purpose In the Netherlands, over 20,000 patients sustain a hip fracture yearly. A first hip fracture is a risk factor for a second,
Burgers, P.T.P.W. (Paul), Heetveld, M.J. (Martin), Lieshout, E.M.M. (Esther) van, Mailuhu, A.K.E. (Adinda), Patka, P. (Peter), Poolman, R.W. (Rudolf), Roukema, G.R. (Gert), Verhofstad, M.H.J. (Michiel), Zielinski, S.M. (Stephanie)   +8 more
core   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Evaluation of the clinical efficacy of using an inverted triangular cannulated compression screw in combination with positive or negative buttress reduction for the healing of femoral neck fractures

BMC Musculoskeletal Disorders
Objective We aimed to compare the clinical efficacy of inverted triangular cannulated compression screws combined with Gotfried positive or negative buttress reduction in the healing of femoral neck fractures. Methods Between October 2017 and March 2021,
Gang Wang, Cui Tang, Yong Tang, Rui Wang, Tugang Shen, Chundao Xu, Jian Yu, Gaokai Li   +7 more
doaj   +1 more source

Percutaneous iliosacral screw fixation in S1 and S2 for posterior pelvic ring injuries: technique and perioperative complications [PDF]

, 2018
Objective: Percutaneous iliosacral screw placement allows for minimally invasive fixation of posterior pelvic ring instabilities. The objective of this study was to describe the technique for screws in S1 and S2 using conventional C-arm and to evaluate ...
Ossendorf, Christian, Osterhoff, Georg, Simmen, Hans-Peter, Wanner, Guido, Werner, Clément   +4 more
core  

Impaired adrenergic regulation of Kv channels underlies LC hyperactivity and early‐onset sleep disruption in AD‐like amyloidogenic mice

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Sleep–wake disturbances frequently occur at early stages of Alzheimer's disease (AD) and accelerate disease progression, but the underlying neural mechanisms are not fully understood. METHODS We examined sleep–wake behavior and locus coeruleus (LC) activity in young 5xFAD mice using electrophysiology and pharmacological approaches
Yi‐Ci Zhang, Xue‐Ting Zhang, Peng‐Yue Chen, Zi‐Yue Zhou, Mao‐Qing Huang, Kai‐Wen He   +5 more
wiley   +1 more source

Biomechanical analysis of a new cannulated screw for unstable femoral neck fractures

Frontiers in Bioengineering and Biotechnology
BackgroundThe treatment of unstable femoral neck fractures (FNFs) remains a challenge. In this study, a new cannulated screw for unstable FNFs was designed to provide a new approach for the clinical treatment of these injuries, and its biomechanical ...
Zhigang Chen, Zhigang Chen, Feiyang Chen, Xinbao Xu, Xin Li, Haidong Cui, Wen Zhang, Dong Jiang, Feixiang Zhang, Yinbing Chen, Shiran Zhou, Shujun Lyu   +11 more
doaj   +1 more source

Mechanical study in vitro of the resistance of axial forces of 3.5 mm cannulated and conventional screws in head and femoral neck fractures [PDF]

Background: Proximal femoral fractures account for 25% of all femoral fractures in dogs and are more common in young animals. Osteosynthesis of femoral head and neck fractures is a complex procedure that can be performed using conventional screws or ...
Baccarin, Daniel Castelo Branco, Ferreira, Márcio Poletto, Ferrigno, Cassio Ricardo Auada, Pereira, César Augusto Martins   +3 more
core  

Fractura subtrocantérica tras fijación percutánea con tornillos de fracturas no desplazadas en el cuello femoral : presentación de tres casos y revisión de la literatura [PDF]

, 2016
Objective. To show 3 cases of subtrochanteric fracture as complication of screw fixation for femoral neck undisplaced fractures. Material and methods. We present 3 cases of subtrochanteric fractures after screw fixation of valgus impacted femoral neck ...
Andrés Peiró, José Vicente, Molero García, V., Reverté Vinaixa, M.M., Teixidor Serra, J., Tomás Hernández, J.   +4 more
core  

KCC2 Dysfunction Mediated by Microglial BDNF/TrkB Signaling Exacerbates Early Post‐Stroke Seizure Susceptibility

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Ischemic stroke induces microglial activation and BDNF–TrkB signaling, leading to KCC2 downregulation and seizure susceptibility. Pharmacological inhibition of microglia or TrkB and restoration of KCC2 function with the chloride extrusion enhancer CLP290 attenuate post‐ischemic seizures.
Jing Zhou, Benjamin H. Wang, Jiangning Yu, Guoxiang Wang, Jingyi Cai, Mohan Yu, Kehua Chen, Li Wan, Xu Liu, Zhigang Yang, Yulong Wang, Yun Wang   +11 more
wiley   +1 more source