Results 161 to 170 of about 157,915 (300)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Obese patient imaging: Potential dose reduction with photon-counting CT. [PDF]

J Appl Clin Med Phys
Liu LP, Mei K, Sharma S, Ross S, Halliburton SS, Thompson R, Akino N, Dhanaliwala AH, Roshkovan L, Litt HI, Noël PB.   +10 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Canon en Ecrevisse // ou // Retrograde // a 4 parties (manuscrit autographe)

Titre uniforme : Gossec, François-Joseph (1734-1829). Compositeur. [Canon en écrevisse ou rétrograde. Violons (2), violoncelles ou bassons (2). RH 254. Si bémol majeur]Titre uniforme : Gossec, François-Joseph (1734-1829). Compositeur.
Gossec, François-Joseph (1734-1829). Compositeur
core  

Canon 644: Education Loans of Those Entering Religious Communities

, 2010
Canon 644 prohibits those "burdened by debts which they cannot repay" from entering the novitiate of a religious institute. Increasingly those who would like to enter religious life have substantial education debt.
Hereford, Judith
core  

Biomimetic Dexterous Hand Control for Robotic Piano Playing Using a Two-Stage Reinforcement Learning Curriculum. [PDF]

Biomimetics (Basel)
Jiang L, Chen J, Lan K, Liu X, Jin Y, Wang H.   +5 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Propolis-Based Solution Application in Extraction Socket Healing: A 3D Split-Mouth Clinical Pilot Study. [PDF]

Cureus
Moussallem GE, Younes R.
europepmc   +1 more source

Evaluation of Large Language Models with clinical guidance for vetting outpatient MRI lumbar spine referrals

The Royal College of Radiologists Open
William Clackett, Hatim Alsusa, Hannah Watson, Antanas Kascenas, David Scott, Avinash K. Kanodia, T. Barry Oliver, Alison Q. O'Neil   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source