Results 111 to 120 of about 444,205 (224)

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Challenges in predicting protein-protein interactions of understudied viruses: Arenavirus-human interactions. [PDF]

Comput Struct Biotechnol J
Sahni H, Crotzer SM, Moore J, Branda SS, Estrada T, Gnanakaran S.   +5 more
europepmc   +1 more source

A Comparative Analysis of a Corporation\u27s Right Against Self-Incrimination [PDF]

, 1995
Baron, Jens Malte, Fietkau, K., Kluwig, D., Lüscher, Bernhard, Marquardt, Yvonne, Pfaff, C.   +5 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

End-tidal carbon dioxide changes induced by passive leg raising can predict fluid responsiveness in patients on veno-arterial extracorporeal membrane oxygenation: a prospective, interventional study. [PDF]

Ann Intensive Care
Hannequin T, Ughetto A, Eliet J, Blin C, Canon A, Saour M, Gaudard P, Vidal C, Molinari N, Colson P, Mourad M.   +10 more
europepmc   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Knowledge, attitudes and risk practices on echinococcosis in Aysén District, Chile. [PDF]

One Health
Sepulveda N, Fresno M, Poblete Y, Cañon Jones H.   +3 more
europepmc   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Arthroscopic Ankle Arthrodesis vs Open Ankle Arthrodesis: A Propensity-Matched, Retrospective Database Analysis of Medical Complications and 2-Year Nonunion Rates. [PDF]

Foot Ankle Orthop
Anastasio AT, Kiritsis NR, Shaffrey IR, Lintz F, Cornelius C, Mansur NS, Dankert J, O'Neill C, de Cesar Netto C.   +8 more
europepmc   +1 more source

Epic Systems Corp. v. Lewis: Singled Out by Corporations and a Textualist Supreme Court, American Workers Are Left to Fend for Themselves [PDF]

, 2019
O\u27Malley, Grace
core   +1 more source