Results 141 to 150 of about 62,166,301 (209)

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Troubling the Canon: Language, Geography, and the Politics of STS Publishing in Five Decades of Journal Publications. [PDF]

Soc Stud Sci
Meloni M, Issaka A, Cadman S, Hegarty B, Chiapperino L, Moll T.   +5 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Automated interstitial lung abnormalities detection at CT: external validation and potential recognition of traction bronchiectasis/bronchiolectasis. [PDF]

Jpn J Radiol
Nakamura Y, Fukuda T, Aoyagi K, Kawagishi M, Ko Y, Wada N, Hino T, Hida T, Vernooij MW, Bos D, Loth DW, Ozaki M, Koga A, Bjarnadottir H, Gudmundsdottir V, Gudmundsson G, Gudnason V, Nishino M, Christiani DC, Hunninghake GM, Ishigami K, Hatabu H.   +21 more
europepmc   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

The NASA ABoVE Land, Vegetation, and Ice Sensor full waveform LiDAR airborne surveys. [PDF]

Sci Data
Hoy EE, Miller CE, Griffith PC, Montesano PM, Hofton M, Yaacoub S, Blair JB, Armstrong A, Brooks C, Cornejo H, Duncanson L, Goetz SJ, Hendry S, Hopf D, Howerton ME, Kaser L, Kimball JS, Larson L, Macander MJ, Mullin M, Rabine D, Smith LC, Story S, Switzer R, Travers-Smith H, Van der Sluijs J, Wei Y, Wu A, Yang D.   +28 more
europepmc   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, EarlyView.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Influence of the Artificial Aging Heat Treatment Regime on the Cavitation Erosion Behavior of the AM50 Alloy. [PDF]

Materials (Basel)
Bordeasu I, Bordeasu D, Tatu FS, Stroita DC, Ghera C.   +4 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Oil Sorption and Oil-Water Separation Using 3D Printed Sorbents Manufactured with Fused Filament Fabrication. [PDF]

Polymers (Basel)
Kántor J, Gergely AL.
europepmc   +1 more source