Results 81 to 90 of about 7,013 (181)

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Air pollution, driver mutations, and survival in non-small cell lung cancer: insights from a high-altitude Hispanic cohort. [PDF]

Transl Lung Cancer Res
Tamayo M, Duque-Clavijo N, Herrera-López AB, Estrada-Schweineberg M, Bejarano AF, Pardo-Aljure J, Baldovino-Chiquillo L, Uscategui-López D, Dueñas-Hernández S, Molina MP, García MJ, Cañon D, Baldión M, Cruz S, Pino LE, Vargas H, Segovia J, Cantor E, Valencia-Estupiñan O, Sarmiento OL, Cardona AF, Wills B.   +21 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Personalisation and profiling using algorithms and not-so-popular Colombian music: goal-directed mechanisms in music emotion recognition. [PDF]

EPJ Data Sci
Gómez-Cañón JS, Lennie TM, Eerola T, Aragón P, Cano E, Herrera P, Gómez E.   +6 more
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

A Comparative Evaluation of Shade Selection Using Digital Photography and the VITA 3D-Master Shade Guide: An In Vitro Study. [PDF]

Cureus
Singh AK, Grover SS, Chandra G, Baishya JK, Pandey S.   +4 more
europepmc   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Surgical compared to percutaneous repair of aortic coarctation in the pediatric population: a protocol for a systematic review and meta-analysis update. [PDF]

Syst Rev
Pérez-Ariza V, Delgado-Pérez MP, Prada SA, Maldonado-Escalante J, Maldonado-Cañón K.   +4 more
europepmc   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Infrared Thermal Imaging as a Predictor of Lumbar Paravertebral Block Effectiveness in Cattle. [PDF]

Animals (Basel)
Viscasillas J, Rave E, Cañón-Pérez A, Marti-Scharfhausen MLR, Hernández-Magaña EZ, Martínez A, Redondo JI, García-Muñoz A.   +7 more
europepmc   +1 more source