Results 71 to 80 of about 254,807 (302)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

open access: yesAdvanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo   +20 more
wiley   +1 more source

Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis

open access: yesAdvanced Science, EarlyView.
In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley   +1 more source

Ethical Problems for the Law Firm of a Former Government Attorney: Firm or Individual Disqualification? [PDF]

open access: yes, 1977
In the area of pricing insurances, many statistical tools are used. The number of tools that exist are overwhelming and it is dicult to know which one to choose.
Bullock, James F.
core   +2 more sources

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network

open access: yesAdvanced Science, EarlyView.
A quasi‐periodic Dart‐Kite (QDK) metastructure with a golden‐ratio‐constrained strong–weak bond network simultaneously enhances strength, toughness, and damage tolerance. Its distributed topology enables predictable, tailorable crack paths for precise fracture control and stable mechanics, demonstrating a high‐performance, controllable architecture ...
Tianyu Gao   +3 more
wiley   +1 more source

The formation of Gratian’s Decretum as an example of the vitality of Roman law

open access: yesPrzegląd Prawniczy Uniwersytetu im. Adama Mickiewicza, 2014
The formation of Gratian’s Decretum as an example of the vitality of Roman law Gratian’s Decretum was one of the most significant legal collections in the history of canon law and was the foundation of canon law science.
Piotr Alexandrowicz
doaj   +1 more source

La teología del Derecho canónico. Nueva disciplina [PDF]

open access: yes, 2006
The recent reform of the Order of studies in the Faculties of Canon Law, carried out by the Decree of 2.IX.02 of the Congregation for Catholic Education, has introduced a new discipline in the Second Cycle of Licentiate, called «Theology of Canon Law ...
Molano, E. (Eduardo)
core  

Unraveling the Power of Disorder: A Bioinspired Cuttlebone Structure With Superior Strength, Energy Absorption and Isotropy

open access: yesAdvanced Science, EarlyView.
Cuttlebone‐inspired architected metamaterials introduce controlled structural disorder to simultaneously enhance strength, energy absorption, and compressive stability. Tunable disorder suppresses shear anisotropy, outperforms periodic lattices, and establishes discrete randomness as a robust route to high‐performance lightweight mechanical ...
Zengqin Shi   +7 more
wiley   +1 more source

Divine Law in Canon 22 of the Code of Canon Law

open access: yesActa Universitatis Lodziensis Folia Iuridica
Civil law norms may operate in the Church’s legal order. Canon law refers to them as a general norm expressed in canon 22 of the Code of Canon Law. This phenomenon is referred to as the canonisation of civil law.
Tomasz Gałkowski
doaj   +1 more source

Джерела канонічного права (теоретико-правовий аналіз) [PDF]

open access: yes, 2005
Місевич С. В. Джерела канонічного права (теоретико-правовий аналіз) : автореф. дис. ... канд. юрид. наук : 12.00.01 / С. В. Місевич; кер. роботи А. А. Козловський ; Нац. ун.-т "Одеська юридична академія". – Одеса, 2005.
Misevych, Sergiy V.   +2 more
core  

Implications of Transient Negative Capacitance Effect in Ferroelectric Polarization Dynamics

open access: yesAdvanced Electronic Materials, EarlyView.
Transient voltage artifacts observed during ferroelectric switching are shown to originate from measurement circuitry rather than intrinsic negative capacitance. By correlating switching current, time scale, and series resistance, this work establishes practical design rules for reliable pulse‐switching experiments and circuit integration of ...
Marin Alexe
wiley   +1 more source

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