Advanced Science, EarlyView.Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu +11 more
wiley +1 more source
Transcriptional regulation of root development in cacao: a genome-wide comparative analysis between zygotic and somatic embryo-derived seedlings. [PDF]
Front Plant SciMakondy REA +5 more
europepmc +1 more source
A corpus-driven standardization framework for encoding clinical problems with HL7 FHIR. [PDF]
J Biomed Inform, 2020 Peterson KJ, Jiang G, Liu H.
europepmc +1 more source
SiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet
Advanced Science, EarlyView.SiDT1 encodes a GA3‐oxidase that creates a semi‐dwarf, lodging‐resistant architecture reminiscent of the rice Green Revolution. The resulting ideotype performs well under dense planting and provides a valuable genetic resource for high‐yield, mechanized foxtail millet production. ABSTRACT Foxtail millet (Setaria italica) is a drought‐tolerant C4 cereal
Jianzhen Lv +13 more
wiley +1 more source
<i>In Situ</i> Temperature-Dependent Properties of Metal-Organic Framework ZIF-Coated ZnO Hybrid Structures: Structural and Advanced Spectroscopic Insights. [PDF]
ACS OmegaNagpal R +14 more
europepmc +1 more source
Advanced Science, EarlyView.Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen +12 more
wiley +1 more source
LINE-1 Transcript Heterogeneity in Non-Small Cell Lung Cancers Is Driven by Host Genomic Context and Conserved Functional Hotspots. [PDF]
Cancers (Basel)Wang Y, Ramos KS.
europepmc +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source
asMODiTS: An application of surrogate models to optimize Time Series symbolic discretization through archive-based training set update strategy. [PDF]
MethodsXMárquez-Grajales A +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu +10 more
wiley +1 more source