Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Stochastic Canonical Correlation Analysis
, 2017 Accepted by ...
Gao, Chao +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Canonical Correlation Analysis of Global Climate Elements and Rainfall in the West Java Regions
Desimal, 2020 Indonesia has a diversity of climate influenced by several global phenomena such as El Nino Southern Oscillation (ENSO), Indian Ocean Dipole (IOD), and Asian-Australian Monsoon.
Arisya Maulina Bowo +2 more
doaj +1 more source
Evaluation, Germination, Seed Vigor and Seedling Emergence and Field Performance of Various Cultivars and Accessions in Red clover (T. pretense L.(, Persian (T. resupinatum L.) and Berseem (T. alexandrinum L.) [PDF]
علوم و فناوری بذر ایران, 2018 In this study, to evaluate the seed vigor tests associated with the seedling field emergence and yield of clover cultivars three separate experiments consisted of germination test and seed accelerated aging test in a completely randomized design with 4 ...
سارا ممبینی, Z. Khodarahmpour
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Minimax estimation in sparse canonical correlation analysis
, 2015 Canonical correlation analysis is a widely used multivariate statistical technique for exploring the relation between two sets of variables. This paper considers the problem of estimating the leading canonical correlation directions in high-dimensional ...
Gao, Chao +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Presenting a model for measurement of the relationship between financial risks and financial ratios [PDF]
مطالعات تجربی حسابداری مالی, 2019 All financial institutions and banks have risks in their operations that have not been able to eliminate them, but there is the possibility of managing these risks.
Bakhtiar Ostadi, Parvin Tadrisi Pajou
doaj +1 more source