Results 121 to 130 of about 14,660 (227)

Comprehensive Integrated Single‐Cell and Spatial Transcriptomics Unveil the Dynamic Landscape of Betel Nut‐Associated Oral Mucosal Carcinogenesis and Its Tumor Microenvironment

MedComm, Volume 7, Issue 6, June 2026.
ABSTRACT Betel nut chewing is a major etiological factor for oral squamous cell carcinoma (OSCC), yet its mechanistic underpinnings remain poorly defined. Here, we performed single‐cell RNA sequencing and spatial transcriptomics from six OSCC patients to comprehensively dissect the tumor microenvironment (TME) dynamics and cellular heterogeneity ...
Wei Dong, Shuojin Huang, Yijun Wu, Congyuan Cao, Jiaxue Li, Qianting He, Anxun Wang   +6 more
wiley   +1 more source

A Novel Technique for Semantic Segmentation of Hyperspectral Images Using Multi-View Features

Applied Sciences
This research presents an innovative technique for semantic segmentation of Hyperspectral Image (HSI) while focusing on its dimensionality reduction. A unique technique is applied to three distinct HSI landcover datasets, Indian Pines, Pavia University ...
Reaya Grewal, Geeta Kasana, Singara Singh Kasana   +2 more
doaj   +1 more source

Deep canonical correlation analysis

, 2013
We introduce Deep Canonical Correlation Analysis (DCCA), a method to learn com-plex nonlinear transformations of two views of data such that the resulting representations are highly linearly correlated.
Jeff Bilmes, Karen Livescu, Galen Andrew
core  

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Instance-specific canonical correlation analysis

, 2015
Canonical Correlation Analysis (CCA) is one of the most popular statistical methods to capture the correlations between two variables. However, it has limitations as a linear and global algorithm. Although some variants have been proposed to overcome the
Wen Gao, Yeung, Dit Yan, Gao, Wen, Dit-Yan Yeung, Zhang, Yu, Chen, Lin, Hong Chang, Zhai, Deming, Yu Zhang, Chang, Hong, Deming Zhai, Yeung, Dit-Yan, Chen, Xilin, Xilin Chen   +13 more
core   +1 more source

Subsurface Ventilation Processes in a Wind‐Driven Coastal System: Insights From the Gulf of Oristano (Italy)

Journal of Geophysical Research: Oceans, Volume 131, Issue 6, June 2026.
Abstract High‐resolution, year‐long observations (2023–2024) were conducted in the Gulf of Oristano, a shallow semi‐enclosed basin on the western coast of Sardinia, to address the scarcity of sustained in situ measurements resolving sub‐seasonal coastal processes in the Mediterranean.
Andrea Cucco, Giovanni Quattrocchi, Alberto Ribotti, Andrea Satta, Tasneem Ahmed, Jacobo Martin, Roberto Sorgente, Angelo Perilli, Fabio Antognarelli, James Dariush Karimi, Massimo Salvatore Giovanni Marras, Roberto Brundu, Matteo Sinerchia   +12 more
wiley   +1 more source

D-CCA: A Decomposition-Based Canonical Correlation Analysis for High-Dimensional Datasets

, 2018
A typical approach to the joint analysis of two high-dimensional datasets is to decompose each data matrix into three parts: a low-rank common matrix that captures the shared information across datasets, a low-rank distinctive matrix that characterizes ...
Hai Shu (6082148), Xiao Wang (19312), Hongtu Zhu (204277)   +2 more
core   +1 more source

Ecological Processes Underpinning Microbial Variability in Archean Granitoids Beneath the Deccan Traps: Evidence From Deep Drilling in Koyna, India

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Deep biosphere hosted by Archean granitoid basement of Deccan Traps showed depth‐wise microbial partitioning. Limited dispersion and variable selection control community assembly. Fewer abundant bacterial taxa were ubiquitous, while large numbers of rare taxa remained localized.
Rajendra Prasad Sahu, Sufia Khannam Kazy, Debarshi Mukherjee, Sukanta Roy, Thomas Wiersberg, Pinaki Sar   +5 more
wiley   +1 more source

Antimicrobial Secondary Metabolites From Rhizosphere‐Associated Streptomyces Species in Northern Nigerian Agricultural Soils: Genomic Mining and Bioactivity Assessment

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
Nigerian agricultural soils harbour diverse Streptomyces species producing novel antimicrobial secondary metabolites. Genomic mining revealed 187 biosynthetic gene clusters, leading to isolation of twelve new compounds with potent activity against multidrug‐resistant pathogens, including MRSA and vancomycin‐resistant Enterococcus. ABSTRACT Streptomyces
David Adeiza Zakari, Sarafadeen Olateju Kareem, Obuotor Tolulope Mobolaji, Akinloye Oluseyi Adeboye, Adefila Moyosore Adebimpe   +4 more
wiley   +1 more source