Results 171 to 180 of about 29,917 (203)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements. [PDF]

Sci Adv
Abbott JA, Kim J, Liu B, Popescu GK, Gouaux E, Jalali-Yazdi F.   +5 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI. [PDF]

Proc Natl Acad Sci U S A
Barmada MI, McGinity EN, Nandi S, Dey D, Zelinskaya N, Harris GM, Comstock LR, Dunham CM, Conn GL.   +8 more
europepmc   +1 more source

Next-generation Janus kinase inhibitors: Integrating synthetic innovation, structural biology, and computational design for precision drug discovery. [PDF]

Pharm Sci Adv
Karunakar KK, Cheriyan BV, Philiph S, Shanmugam RK, Sree J.   +4 more
europepmc   +1 more source

Parkinson's Disease: From Gene-Environment Risk to Precision Therapy. [PDF]

Med Sci (Basel)
Arias-Carrión O.
europepmc   +1 more source

Hypoparathyroidism: a brief historical overview for clinicians. [PDF]

Front Endocrinol (Lausanne)
Díez JJ.
europepmc   +1 more source

It's all connected! Multivariate pattern analysis of inter-network connectivity distinguishes between reappraisal and passive viewing of emotional scenes. [PDF]

Cereb Cortex
Horner S, Rawliuk T, Ferstl RM, Lyons AL, Martin J, Gorbet DJ, Stevens WD, Greening SG.   +7 more
europepmc   +1 more source

Effects of Salinity on the Reproductive and Lifespan Traits of <i>Artemia</i> Parthenogenetic Lineages with Different Ploidy Levels. [PDF]

Biology (Basel)
Asem A, Li Y, Yan X, Zhang Y, Zhu Y, Kangarloei BA, Yang C.   +6 more
europepmc   +1 more source