Results 181 to 190 of about 11,911,049 (290)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

How can "small childcare" support "great happiness"? A study on inclusive childcare services for infants and toddlers aged 0-3 in Guangxi through the lens of the capability approach. [PDF]

Front Public Health
Chen Z, Liu J, Li C, Kang Q, Tang Y.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Exploring the application of the capability approach to the health and well-being of Indigenous Peoples: a scoping review. [PDF]

Glob Ment Health (Camb)
Chaparro Rojas LA, De La Cruz PE, Chiumento A, Van der Boor CF, Molina-Bulla CI, Baquero Vargas MP, Sánchez Díaz GC, Agudelo-Ortiz DM, Guevara Morales LJ, Aponte-Canencio DM, White RG.   +10 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Entrepreneurship and Human Development: A Capability Approach [PDF]

We provide a formal model of entrepreneurship in human development. The framework is provided by the capabilities approach (CA). Hence we extend not only the conceptualisation of entrepreneurship in development, but the reach of the CA into ...
Naudé, Wim, Gries,Thomas
core  

Effectively supporting widening participation learners in medical education through a capability approach lens. [PDF]

Int J Med Educ
Vivekananda-Schmidt P, Sandars J, Husain L, Leadbetter P, Marshall M.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Health assessment and the capability approach. [PDF]

Glob Bioeth, 2019
López Barreda R, López Barreda R, Robertson-Preidler J, Bedregal García P.   +3 more
europepmc   +1 more source