Results 81 to 90 of about 659,431 (267)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dynamic Capabilities: exploring industry level capabilities in UK Publishing [PDF]

, 2015
The competitive dynamics of many industries have changed considerably over the past decade and perhaps none more so than in news media. There is no doubt that this industry continues to undergo structural changes that compel news media firms to adapt and transform their business in response to the dynamic nature of media environment (Oliver, 2012; 2014)
openaire  

The Influence of Legal Environment and Levels of Integration on Retailer Capabilities

, 2017
info:eu-repo/semantics ...
Castillo López, Juan José, Fabra Florit, María Eugenia, Labajo González, María Victoria   +2 more
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Are Levels of Loneliness Associated With Levels of Comfort and Capability in Musculoskeletal Illness?

Clinical Orthopaedics & Related Research
Background Variation in levels of pain intensity and incapability among patients with musculoskeletal conditions is associated with measures of mindset (unhelpful thoughts [such as hurt equals harm] and feelings of distress [overwhelm, rumination] regarding bodily sensations) and circumstances (social health as ...
Haley Ponce, Rafael Cordero, David Ring, George Sayegh, Ali Azarpey, Prakash Jayakumar   +5 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

IT Proficiency in A Media and Publishing Company Using the COBIT 2019 Framework

Journal of Information Systems and Informatics
Information technology plays a pivotal role in enhancing company performance by streamlining data management processes. The company, currently transitioning from the SAP ERP system to the Odoo ERP system, faces significant challenges, particularly ...
Kevin Kevin, Johan Setiawan
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Impact of Level-Converter on Power-Saving Capability of Clustered Voltage Scaling [PDF]

Advances in Radio Science, 2005
The use of multiple supply voltages to reduce active mode power dissipation in digital ULSI circuits has been widely discussed in literature. As the reported power savings differ significantly depending on the technology and level converter circuits an ...
St. Henzler, J. Berthold, M. Koban, M. Reinl, G. Georgakos, D. Schmitt-Landsiedel   +5 more
doaj  

DESTINY: A Comprehensive Tool with 3D and Multi-Level Cell Memory Modeling Capability

Journal of Low Power Electronics and Applications, 2017
To enable the design of large capacity memory structures, novel memory technologies such as non-volatile memory (NVM) and novel fabrication approaches, e.g., 3D stacking and multi-level cell (MLC) design have been explored.
Sparsh Mittal, Rujia Wang, Jeffrey Vetter   +2 more
doaj   +1 more source