Results 101 to 110 of about 204,415 (295)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Project maturity evaluation model for SMEs from the software development sub-sector

AD-minister, 2016
The purpose of the paper is to present a project management maturity model for SMEs oriented to software development. The proposal is based on CMMI capability maturity model, and the SCAMPI evaluation method.
Álvaro Julio Cuadros López, Carolina Galindres, Paola Ruiz   +2 more
doaj   +1 more source

Kesediaan pelajar politeknik kejuruteraan elektrik dalam menceburi bidang keusahawanan [PDF]

, 2012
Bidang keusahawanan kini semakin berkembang maju selaras dengan seruan kerajaan yang banyak memberi dorongan kepada rakyat Malaysia agar menjadikan usahawan sebagai kerjaya utama. Kajian yang dijalankan adalah untuk mengenal pasti kesediaan pelajar
Mohd Halid, Nurul Nadhilah
core  

Dynamic Capabilities for the Twin Transformation Climb: A Capability Maturity Model

Information Systems Frontiers
Abstract Digital transformation and sustainability transformation are at the top of organizations’ agendas to remain competitive. While guidance on both transformations exists separately, even more research on integrating digital and sustainability transformation, namely twin transformation, is required.
Katharina Breiter, Carlotta Crome, Anna Maria Oberländer, Feline Schnaak   +3 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Risk Assessment Maturity Level of Academic Information System Using ISO 27001 System Security Engineering-Capability Maturity Model

Journal of Applied Engineering and Technological Science
Risk measurement from standard operating procedures implemented by an institution determines the level of maturity of a service system at that institution.
Nurbojatmiko Nurbojatmiko, Qurrotul Aini, Nabil Cahya Wasiqi, Muhammad Fitra Alfajri, Zahra Ulinnuha, Yuni Kurnia Purwati, Indah Kusuma Ayu, Natasya Aurora Yasmin   +7 more
doaj   +1 more source

An evaluation of the RAPID assessment-based process improvement method for small firms [PDF]

, 2005
[Abstract]: With increasing interest by the software development community in software process improvement (SPI), it is vital that SPI programs are evaluated and the reports of lessons learned disseminated.
Cater-Steel, Aileen, Rout, Terry, Toleman, Mark   +2 more
core