Results 41 to 50 of about 54,628 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Equipotential shielding voltage sensor for contact measurement of transient voltage in EHV/UHV power grids

open access: yesHigh Voltage, 2021
In this study, an equipotential shielding voltage sensor is proposed to achieve contact measurement of transient voltage in extra‐high voltage (EHV)/ultra‐high voltage (UHV) power grids.
Jianchao Zheng   +4 more
doaj   +1 more source

Low Value Capacitance Measurement System with Adjustable Lead Capacitance Compensation

open access: yes, 2013
The present paper describes the development of a low cost, highly accurate low capacitance measurement system that can be used over a range of 0 – 400 pF with a resolution of 1 pF.
Kesab Bhattacharya   +3 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Silicone Oil Decreases Biofilm Formation in a Capacitance-Based Automatic Urine Measurement System

open access: yesSensors, 2021
Capacitance-based automatic urine measurement is a validated technique already implemented in clinical practice. However, albuminuria and free hemoglobinuria cause progressive biofilm buildup on the capacitance sensors of the urinometers. The aim of this
Martin Slettengren   +2 more
doaj   +1 more source

Frequency estimation techniques in capacitance-to-frequency conversion measurement

open access: yes, 2020
The process of capacitance measurement consists of converting the capacitance under measurement into a secondary variable such as voltage, time-period, and frequency.
Tushar Tyagi   +3 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

An Electrical Capacitance Array for Imaging of Water Leakage inside Insulating Slabs with Porous Cells

open access: yesSensors, 2019
The paper proposes a capacitance-sensor-array-based imaging system to detect water leakage inside insulating slabs with porous cells, such as anechoic acoustic rubber tiles.
Rui Li, Yi Li, Lihui Peng
doaj   +1 more source

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