Results 141 to 150 of about 6,426,315 (314)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Development of a risk modeling approach to enhance the effectiveness of epidemic preparedness, response, and financing strategies in African countries

International Journal of Infectious Diseases, 2020
N. Madhav, H. Kyobe Bosa, R.K. Degraft Agyarko, N. Stephenson, K. Miller, M. Gallivan, C. Lam, A. Meadows, V. Sridharan, A. Bah, M. Béavogui   +10 more
doaj   +1 more source

Impact of hydropower availability on resource adequacy of the United States western interconnection. [PDF]

PLoS One
Sunkara SV, Sundar S, Stephen G, Cohen S, Reed P, Srikrishnan V, Miara A.   +6 more
europepmc   +1 more source

Design of capacity-approaching irregular low-density parity-check codes

IEEE Transactions on Information Theory, 2001
T. Richardson, A. Shokrollahi, R. Urbanke   +2 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

8 years of strengthening AMR response capacity in the WHO African region (2017-2024): progress in antimicrobial consumption monitoring, surveillance and laboratory capacity. [PDF]

BMJ Public Health
Gahimbare L, Iwu-Jaja C, Mazengiya YD, Coulibaly SO, Lugor LRZ, Mwamelo AJ, Olu OO, Yahaya AA.   +7 more
europepmc   +1 more source

Mobility increases the capacity of ad-hoc wireless networks

Proceedings IEEE INFOCOM 2001. Conference on Computer Communications. Twentieth Annual Joint Conference of the IEEE Computer and Communications Society (Cat. No.01CH37213), 2001
M. Grossglauser, David Tse
semanticscholar   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An advanced reliability reserve incentivizes flexibility investments while safeguarding the electricity market. [PDF]

iScience
Klaucke F, Neuhoff K, Roth A, Schill WP, Stolle L.   +4 more
europepmc   +1 more source

The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease.

New England Journal of Medicine, 2004
B. Celli, C. Côté, J. Marin, C. Casanova, M. Montes de Oca, R. Mendez, V. Pinto Plata, Howard Cabral   +7 more
semanticscholar   +1 more source