Results 191 to 200 of about 2,268,216 (315)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Embed capacity development within all global health research. [PDF]

BMJ Glob Health, 2021
Adegnika AA, Amuasi JH, Basinga P, Berhanu D, Medhanyie AA, Okwaraji YB, Persson LÅ, Savadogo B, Schellenberg J, Steinmann P.   +9 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Capacity Development of Local Service Organizations Through Regional Innovation in Papua, Indonesia After the COVID-19 Pandemic. [PDF]

Front Psychol, 2022
Prasetyo A, Gartika D, Hartopo A, Harwijayanti BP, Sukamsi S, Fahlevi M.   +5 more
europepmc   +1 more source

Capacity for Sport for Development

, 2018
This dissertation explores the management of local sport for development (SFD) in Canada. It uncovers the organizational capacity for local SFD, the processes involved in building capacity to achieve social change through sport, and the perceptions and experiences of National Sport Organization (NSO) leaders regarding SFD. Study 1 explores and uncovers
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Promising Practices in Capacity Development for Health Supply Chains in Resource-Constrained Countries. [PDF]

Glob Health Sci Pract
Duwiejua M, Steele P, Lalvani P, Leab D, Matowe L, Moody J.   +5 more
europepmc   +1 more source

Capacity development and safety measures for health care workers exposed to COVID-19 in Bangladesh. [PDF]

BMC Health Serv Res, 2021
Nath TK, Paul A, Sikdar D, Mahanta J, Paul S, Amin MR, Chowdhury S, Bhuiyan MNH, Rob MA, Rahim A, Islam MK, Sharif MM, Navaneetham K.   +12 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Healthy Aging Outcomes Research With Villages as Grassroots Community-Based Organizations: A Framework for Capacity Development. [PDF]

Gerontologist
Greenfield EA, Pope NE.
europepmc   +1 more source